ArticleJournal of neuropathology and experimental neurology2012
Differential effects of FK506 on structural and functional axonal deficits after diffuse brain injury in the immature rat.
Article in Journal of neuropathology and experimental neurology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 30 citations in OpenAlex.
- Development of a paediatric model of diffuse traumatic brain injury in ferrets.Scientific reports · 2026Article
- Repeated mild closed head injury in neonatal rats results in sustained cognitive deficits associated with chronic microglial activation and neurodegeneration.Journal of neuropathology and experimental neurology · 2023Article
- Abusive Head Trauma Animal Models: Focus on Biomarkers.International journal of molecular sciences · 2023Review
- Acute axon damage and demyelination are mitigated by 4-aminopyridine (4-AP) therapy after experimental traumatic brain injury.Acta neuropathologica communications · 2022Article
- Peering into the Brain through the Retrosplenial Cortex to Assess Cognitive Function of the Injured Brain.Neurotrauma reports · 2021Article
- A Pro-social Pill? The Potential of Pharmacological Treatments to Improve Social Outcomes After Pediatric Traumatic Brain Injury.Frontiers in neurology · 2021Review
- Trophic factors are essential for the survival of grafted oligodendrocyte progenitors and for neuroprotection after perinatal excitotoxicity.Neural regeneration research · 2020Article
- Stem Cell Therapy for Pediatric Traumatic Brain Injury.Frontiers in neurology · 2020Review
- Therapeutic strategies to target acute and long-term sequelae of pediatric traumatic brain injury.Neuropharmacology · 2019Review
- Pre-clinical models in pediatric traumatic brain injury-challenges and lessons learned.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2017Review
- Variation in PPP3CC Genotype Is Associated with Long-Term Recovery after Severe Brain Injury.Journal of neurotrauma · 2017Article
- Combination Therapies for Traumatic Brain Injury: Retrospective Considerations.Journal of neurotrauma · 2016Article
- A Novel Approach for Studying the Physiology and Pathophysiology of Myelinated and Non-Myelinated Axons in the CNS White Matter.PloS one · 2016Article
- Neurotrophic Effects of Mu Bie Zi (Momordica cochinchinensis) Seed Elucidated by High-Throughput Screening of Natural Products for NGF Mimetic Effects in PC-12 Cells.Neurochemical research · 2015Article
- Role of Microvascular Disruption in Brain Damage from Traumatic Brain Injury.Comprehensive Physiology · 2015Review
- Toll-like receptor 4 enhancement of non-NMDA synaptic currents increases dentate excitability after brain injury.Neurobiology of disease · 2015Article
- Calcium signaling is implicated in the diffuse axonal injury of brain stem.International journal of clinical and experimental pathology · 2015Article
- Diffuse axonal injury in brain trauma: insights from alterations in neurofilaments.Frontiers in cellular neuroscience · 2014Review
- Oligodendrocyte lineage and subventricular zone response to traumatic axonal injury in the corpus callosum.Journal of neuropathology and experimental neurology · 2013Article
- Pre-Clinical and Clinical Therapies for Traumatic Brain Injury: Where Do We Stand in Pediatrics?Neurotrauma reportsReview
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Diffuse axonal injury is a major component of traumatic brain injury in children and correlates with long-term cognitive impairment. Traumatic brain injury in adult rodents has been linked to a decrease in compound action potential (CAP) in the corpus callosum, but information on trauma-associated diffuse axonal injury in immature rodents is limited. We investigated the effects of closed head injury on CAP in the corpus callosum of 17-day-old rats. The injury resulted in CAP deficits of both myelinated and unmyelinated fibers in the corpus callosum between 1 and 14 days postinjury (dpi). These deficits were accompanied by intra-axonal dephosphorylation of the 200-kDa neurofilament subunit (NF200) at 1 and 3 dpi, a decrease in total NF200 at 3 dpi and axonal degeneration at 3 and 7 dpi. Although total phosphatase activity decreased at 1 dpi, calcineurin activity was unchanged. The calcineurin inhibitor, FK506, significantly attenuated the injury-induced NF200 dephosphorylation of NF200 at 3 dpi and axonal degeneration at 3 and 7 dpi but did not affect the decrease in NF200 protein levels or impaired axonal transport. FK506 had no effect on CAP deficits at 3 dpi but exacerbated the deficit in only the myelinated fibers at 7 dpi. Thus, in contrast to adult animals, FK506 treatment did not improve axonal function in brain-injured immature animals, suggesting that calcineurin may not contribute to impaired axonal function.
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