ArticleBMC pediatrics2012
Early eczema and the risk of childhood asthma: a prospective, population-based study.
Article in BMC pediatrics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
40 citing papers in PubMed, 1 synthesis or guideline pooled it, 99 citations in OpenAlex.
- Meta-analysis identifies seven susceptibility loci involved in the atopic march.Nature communications · 2015Pooled it
- Prevalence, severity, and risk factors of eczema among young children and adolescents in Saudi Arabia: A national cross-sectional study, 2019.The journal of allergy and clinical immunology. Global · 2024Article
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- The relationship between childhood atopic dermatitis and asthma in an under resourced community.Allergy and asthma proceedings · 2024Article
- Moderate to severe atopic dermatitis in children: focus on systemic Th2 cytokine receptor antagonists and Janus kinase inhibitors.Clinical and experimental pediatrics · 2024Article
- Pharmacological importance of Kunxian Capsule in clinical applications and its adverse effects: A review.Chinese herbal medicines · 2023Review
- The hen and the egg question in atopic dermatitis: allergy or eczema comes first.Asthma research and practice · 2023Review
- Association of Severe Bronchiolitis during Infancy with Childhood Asthma Development: An Analysis of the ECHO Consortium.Biomedicines · 2022Article
- Atopic Dermatitis: Clinical Aspects and Unmet Needs.Biomedicines · 2022Review
- Risk Factors Affecting Development and Persistence of Preschool Wheezing: Consensus Document of the Emilia-Romagna Asthma (ERA) Study Group.Journal of clinical medicine · 2022Article
- Context-dependent function of TSLP and IL-1β in skin allergic sensitization and atopic march.Nature communications · 2022Article
- Clinical Characteristics of Atopic Dermatitis in Korean School-Aged Children and Adolescents According to Onset Age and Severity.Journal of Korean medical science · 2022Article
- Bidirectional associations between eosinophils, basophils, and lymphocytes with atopic dermatitis: A multivariable Mendelian randomization study.Frontiers in immunology · 2022Article
- Exhaled volatilome analysis as a useful tool to discriminate asthma with other coexisting atopic diseases in women of childbearing age.Scientific reports · 2021Article
- Clinical and Economic Burden of Mild-to-Moderate Atopic Dermatitis in the UK: A Propensity-Score-Matched Case-Control Study.Dermatology and therapy · 2021Article
- Early life microbial exposures and allergy risks: opportunities for prevention.Nature reviews. Immunology · 2021Review
- Preventing Atopic Diseases During Childhood - Early Exposure Matters.Frontiers in immunology · 2021Review
- Serum IgE Predicts Difference of Population and Allergens in Allergic Diseases: Data from Weifang City, China.Mediators of inflammation · 2021Article
- Childhood Allergy Disease, Early Diagnosis, and the Potential of Salivary Protein Biomarkers.Mediators of inflammation · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSevere eczema in young children is associated with an increased risk of developing asthma and rhino-conjunctivitis. In the general population, however, most cases of eczema are mild to moderate. In an unselected cohort, we studied the risk of current asthma and the co-existence of allergy-related diseases at 6 years of age among children with and without eczema at 2 years of age.
methodsQuestionnaires assessing various environmental exposures and health variables were administered at 2 years of age. An identical health questionnaire was completed at 6 years of age. The clinical investigation of a random subsample ascertained eczema diagnoses, and missing data were handled by multiple imputation analyses.
resultsThe estimate for the association between eczema at 2 years and current asthma at 6 years was OR=1.80 (95% CI 1.10-2.96). Four of ten children with eczema at 6 years had the onset of eczema after the age of 2 years, but the co-existence of different allergy-related diseases at 6 years was higher among those with the onset of eczema before 2 years of age.
conclusionsAlthough most cases of eczema in the general population were mild to moderate, early eczema was associated with an increased risk of developing childhood asthma. These findings support the hypothesis of an atopic march in the general population.
trial registrationThe Prevention of Allergy among Children in Trondheim study has been identified as ISRCTN28090297 in the international Current Controlled Trials database.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.