ArticleNeuroepidemiology2013
Age of onset: can we rely on essential tremor patients to report this? Data from a prospective, longitudinal study.
Article in Neuroepidemiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Developing a Staging Scheme for Essential Tremor: A Discussion of Organizing Principles.Tremor and other hyperkinetic movements (New York, N.Y.) · 2023Article
- Diagnosis and Treatment of Essential Tremor.Continuum (Minneapolis, Minn.) · 2022Review
- Essential tremor: the most common form of cerebellar degeneration?Cerebellum & ataxias · 2020Review
- Graph theory analysis of resting-state functional magnetic resonance imaging in essential tremor.Human brain mapping · 2019Article
- Climbing fiber-Purkinje cell synaptic pathology across essential tremor subtypes.Parkinsonism & related disorders · 2018Article
- Stability and change in reported age of onset of depression, back pain, and smoking over 29 years in a prospective cohort study.Journal of psychiatric research · 2017Article
- Cerebellar Pathology in Early Onset and Late Onset Essential Tremor.Cerebellum (London, England) · 2017Article
- Medication non-adherence in essential tremor.Parkinsonism & related disorders · 2015Article
- 'Essential tremor' or 'the essential tremors': is this one disease or a family of diseases?Neuroepidemiology · 2014Review
- 'When did my tremor start?': can essential tremor patients pinpoint their disease onset?.Neuroepidemiology · 2013Article
- The timing of tremor: a biological clock in essential tremor?Neuroepidemiology · 2013Article
- When do essential tremor patients develop head tremor? Influences of age and duration and evidence of a biological clock.Neuroepidemiology · 2013Article
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Abstract
backgroundEssential tremor (ET) is among the most prevalent neurological diseases. Age of onset, a key variable in neuroepidemiological and genetic research, is chiefly assessed by self-report rather than medical record review; the latter may be of little use. As a researcher, one wonders about the quality of this self-report. Is age of onset something which can be reproducibly self-reported by patients? There are few published data to aid researchers.
methodsAge of onset was self-reported at two time points (baseline and follow-up) in 86 ET cases in a longitudinal epidemiological study in New York.
resultsThe mean follow-up interval was 5.7 ± 2.5 (maximum = 14) years. Overall, agreement between the baseline and follow-up reports was high (ρ = 0.85, p < 0.001). Yet the difference (age of onset (baseline) - age of onset (follow-up)) ranged widely (from -47 to 32 years), and in one fifth of cases was ≥ 10 years. Greater agreement was associated with several clinical factors including age, medication use, embarrassment, depressive symptoms, cognitive test score and disease duration.
conclusionsDifferences in reported age of onset in ET may vary widely, and in up to one fifth of patients may be substantial. Investigators should approach these self-reports with caution.
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