ArticleNephron. Experimental nephrology2012
A novel mouse model of podocyte depletion.
Article in Nephron. Experimental nephrology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed, 11 citations in OpenAlex.
- High glucose reduces expression of podocin in cultured human podocytes by stimulating TRPC6.American journal of physiology. Renal physiology · 2019Article
- Nephron, Wilms' tumor-1 (WT1), and synaptopodin expression in developing podocytes of mice.Experimental animals · 2017Article
- Can podocytes be regenerated in adults?Current opinion in nephrology and hypertension · 2017Review
- Surges in proteinuria are associated with plasma GL-3 elevations in a young patient with classic Fabry disease.European journal of pediatrics · 2016Article
- Wnt/β-catenin signalling and podocyte dysfunction in proteinuric kidney disease.Nature reviews. Nephrology · 2015Review
- Lovastatin inhibits human B lymphoma cell proliferation by reducing intracellular ROS and TRPC6 expression.Biochimica et biophysica acta · 2014Article
- Augmenting podocyte injury promotes advanced diabetic kidney disease in Akita mice.Biochemical and biophysical research communications · 2014Article
- High glucose induces podocyte apoptosis by stimulating TRPC6 via elevation of reactive oxygen species.Biochimica et biophysica acta · 2013Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
aimThe goal of this study was to examine the capacity for glomerular repair after a podocyte-depleting injury.
methodsWe created transgenic (TG) mice expressing the yeast enzyme cytosine deaminase specifically in glomerular podocytes. In these TG animals, the prodrug 5-flucytosine (5-FC) is converted to 5-fluorouracil and promotes cell death.
resultsTreatment with increasing dosages of 5-FC caused graded increases in proteinuria 1-2 weeks after treatment, which returned to control levels by the 10-week time point. Light microscopic examination revealed minimal pathology at the 2-week time point, but electron microscopy revealed found foot process effacement as well as focal areas of glomerular basement membrane duplication, and immunohistochemical studies detected podocyte apoptosis and a decrease in the number of Wilms' tumor protein 1 (WT1)-positive cells. By the 10-week time point, however, the number of WT1-positive cells was similar to controls and a few mice had developed focal areas of glomerulosclerosis. Consistent with the effects of 5-FC on podocyte number, expression of the podocyte mRNAs for nephrin, podocin, synaptopodin and podocalyxin were altered in a similar temporal fashion.
conclusionThe glomerulus has a significant capacity for repair after a podocyte-depleting injury.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.