ArticleJournal of natural products2012
Production of cytotoxic glidobactins/luminmycins by Photorhabdus asymbiotica in liquid media and live crickets.
Article in Journal of natural products, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed.
- ExploringMolecules (Basel, Switzerland) · 2024Review
- Beyond Soil-Dwelling Actinobacteria: Fantastic Antibiotics and Where to Find Them.Antibiotics (Basel, Switzerland) · 2022Review
- Review
- An Overview of Antimicrobial Compounds from African Edible Insects and Their Associated Microbiota.Antibiotics (Basel, Switzerland) · 2021Review
- Activation, Structure, Biosynthesis and Bioactivity of Glidobactin-like Proteasome Inhibitors from Photorhabdus laumondii.Chembiochem : a European journal of chemical biology · 2021Article
- Natural product scaffolds as inspiration for the design and synthesis of 20S human proteasome inhibitors.RSC chemical biology · 2020Article
- Symbiosis, virulence and natural-product biosynthesis in entomopathogenic bacteria are regulated by a small RNA.Nature microbiology · 2020Article
- CRAGE enables rapid activation of biosynthetic gene clusters in undomesticated bacteria.Nature microbiology · 2019Article
- Natural product diversity associated with the nematode symbionts Photorhabdus and Xenorhabdus.Nature microbiology · 2017Article
- Secondary Metabolites Produced byJournal of nematology · 2017Article
- Stilbene epoxidation and detoxification in aThe Journal of biological chemistry · 2017Article
- Solid-phase enrichment and analysis of electrophilic natural products.Beilstein journal of organic chemistry · 2017Article
- Elucidation of the Photorhabdus temperata Genome and Generation of a Transposon Mutant Library To Identify Motility Mutants Altered in Pathogenesis.Journal of bacteriology · 2015Article
- An insecticidal compound produced by an insect-pathogenic bacterium suppresses host defenses through phenoloxidase inhibition.Molecules (Basel, Switzerland) · 2014Article
- Recent advances in natural product discovery.Current opinion in biotechnology · 2014Review
- Attenuated virulence and genomic reductive evolution in the entomopathogenic bacterial symbiont species, Xenorhabdus poinarii.Genome biology and evolution · 2014Article
- Production of proteasome inhibitor syringolin A by the endophyte Rhizobium sp. strain AP16.Applied and environmental microbiology · 2014Article
- Merging chemical ecology with bacterial genome mining for secondary metabolite discovery.Journal of industrial microbiology & biotechnology · 2014Review
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Photorhabdus asymbiotica engages in a two-part life cycle that requires adaptation to both symbiotic and pathogenic phases. The genome of P. asymbiotica contains several gene clusters, which are predicted to be involved in the biosynthesis of unique secondary metabolites that are hypothesized to enhance the bacterium's pathogenic capabilities. However, recent reports on Photorhabdus secondary metabolite production have indicated that many of its genes are silent under laboratory culture conditions. Using a circumscribed panel of media and alternative fermentation conditions, we have successfully achieved the production of a series of new and known glidobactin/luminmycin derivatives from P. asymbiotica including glidobactin A (1), luminmycin A (2), and luminmycin D (3). These compounds were also obtained upon infection of live crickets with the bacterium. Luminmycin D showed cytotoxicity against human pancreatic cells (IC50 of 0.11 μM), as well as proteasome inhibition (IC50 of 0.38 μM).
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Registered trials
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