ArticleCancer science2013
Early response and local control of stage I non-small-cell lung cancer after stereotactic radiotherapy: difference by histology.
Article in Cancer science, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Changes in volume of stage I non-small-cell lung cancer during stereotactic body radiotherapy.Radiation oncology (London, England) · 2014Trial
- Comparative survival analysis of stage T1-T2N0M0 lung squamous cell carcinoma and adenocarcinoma using SEER data, and nomogram analysis for early-stage lung squamous cell carcinoma.Translational cancer research · 2025Article
- SETD2 regulates gene transcription patterns and is associated with radiosensitivity in lung adenocarcinoma.Frontiers in genetics · 2022Article
- Comparison of stereotactic body radiotherapy and radiofrequency ablation for early-stage non-small cell lung cancer: a systematic review and meta-analysis.Annals of translational medicine · 2022Article
- Prognostic Radiological Tools for Clinical Stage IA Pure Solid Lung Cancer.Current oncology (Toronto, Ont.) · 2021Article
- Correspondence: Abnormal Nuclear Variations in Response to Radiotherapy: As a Tool in Treatment Planning and Assessment of Prognosis.Journal of clinical and diagnostic research : JCDR · 2017Article
- Clinical outcomes of stage I and IIA non-small cell lung cancer patients treated with stereotactic body radiotherapy using a real-time tumor-tracking radiotherapy system.Radiation oncology (London, England) · 2017Article
- Impact of early tumor reduction on outcome differs by histological subtype in stage III non-small-cell lung cancer treated with definitive radiotherapy.International journal of clinical oncology · 2016Article
- Robotic stereotactic body radiation therapy for elderly medically inoperable early-stage non-small cell lung cancer.Lung Cancer (Auckland, N.Z.) · 2013Article
- Stereotactic Body Radiotherapy for Early-Stage Non-Small Cell Lung Cancer: When and Why Is It Appropriate Therapy?Journal of the advanced practitioner in oncologyReview
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Authors and funding
4 authors.
Funding
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Abstract
To investigate the possible influences of various factors on tumor response to radiation, regression speeds and long-term local control rates of primary adenocarcinoma and squamous cell carcinoma of the lung after stereotactic body radiotherapy were evaluated. Ninety-one patients (65 men and 26 women) with a median age of 76 years were serially examined using computed tomography at 2, 4 and 6 months after treatment. Tumor histology was adenocarcinoma in 62 patients and squamous cell carcinoma in 29 patients. The prescribed dose was 48 Gy in four fractions given twice a week for T1 tumors (≤ 3 cm) and 52 Gy in four fractions given twice a week for T2 tumors (3-5 cm). Tumor shrinkage speed and 3-year local control rates were similar between T1 and T2 tumors and between patients with normal pulmonary function and those with impaired function. Squamous cell carcinomas shrank faster than adenocarcinomas at 2 and 4 months after radiation, but mean relative tumor size at 6 months and local control rates at 3 years did not differ significantly between the two histologies. Tumors in patients with a higher hemoglobin level tended to shrink faster but the control rates were not different. It is concluded that, although squamous cell carcinoma shrinks faster than adenocarcinoma, the two types of lung cancer are of similar radiosensitivity in terms of long-term control rates. Radiosensitivity should not be evaluated by early tumor response.
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