ArticleJournal of neurotrauma2013
The effect of environmental enrichment on substantia nigra gene expression after traumatic brain injury in rats.
Article in Journal of neurotrauma, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 25 citations in OpenAlex.
- Transcriptional Profiling in a Novel Swine Model of Traumatic Brain Injury.Neurotrauma reports · 2022Article
- Minocycline blocks traumatic brain injury-induced alcohol consumption and nucleus accumbens inflammation in adolescent male mice.Brain, behavior, and immunity · 2018Article
- LPS induces dopamine depletion and iron accumulation in substantia nigra in rat models of Parkinson's disease.International journal of clinical and experimental pathology · 2018Article
- Environmental Enrichment Mitigates Deficits after Repetitive Mild Traumatic Brain Injury.Journal of neurotrauma · 2017Article
- Impact of Traumatic Brain Injury on Dopaminergic Transmission.Cell transplantation · 2017Review
- Factors affecting increased risk for substance use disorders following traumatic brain injury: What we can learn from animal models.Neuroscience and biobehavioral reviews · 2017Review
- The Therapeutic Efficacy of Environmental Enrichment and Methylphenidate Alone and in Combination after Controlled Cortical Impact Injury.Journal of neurotrauma · 2017Article
- Adolescent Traumatic Brain Injury Induces Chronic Mesolimbic Neuroinflammation with Concurrent Enhancement in the Rewarding Effects of Cocaine in Mice during Adulthood.Journal of neurotrauma · 2017Article
- Catecholaminergic based therapies for functional recovery after TBI.Brain research · 2016Review
- Where Environment Meets Cognition: A Focus on Two Developmental Intellectual Disability Disorders.Neural plasticity · 2016Review
- The Controlled Cortical Impact Model of Experimental Brain Trauma: Overview, Research Applications, and Protocol.Methods in molecular biology (Clifton, N.J.) · 2016Review
- Found in translation: Understanding the biology and behavior of experimental traumatic brain injury.Neuroscience and biobehavioral reviews · 2015Review
- Expression of three topologically distinct membrane proteins elicits unique stress response pathways in the yeast Saccharomyces cerevisiae.Physiological genomics · 2015Article
- Environmental enrichment as a viable neurorehabilitation strategy for experimental traumatic brain injury.Journal of neurotrauma · 2014Article
- Traumatic brain injury and post-acute decline: what role does environmental enrichment play? A scoping review.Frontiers in human neuroscience · 2013Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Experimental investigations into the effects of traumatic brain injury (TBI) have demonstrated significant alterations in dopaminergic systems. Dopaminergic fibers originating within the substantia nigra and ventral tegmental area (VTA) are important for reward learning, addiction, movement, and behavior. However, little is known about the effect of TBI on substantia nigra and VTA function. Environmental enrichment (EE) has been shown to improve functional outcome after TBI, and a number of studies suggest that it may exert some benefits via dopaminergic signaling. To better understand the role of dopamine in chronic TBI pathophysiology and the effect of EE, we examined the mRNA expression profile within the substantia nigra and VTA at 4 weeks post-injury. Specifically, three comparisons were made: 1) TBI versus sham, 2) sham+EE versus sham+standard (STD) housing, and 3) TBI+EE versus TBI+STD. There were differential expressions of 25, 4, and 40 genes in these comparisons, respectively. Chronic alterations in genes post-injury within the substantia nigra and VTA included genes important for cellular membrane homeostasis and transcription. EE-induced gene alterations after TBI included genes important for signal transduction, in particular calcium signaling pathways, membrane homeostasis, and metabolism. Elucidation of these alterations in gene expression within the substantia nigra and VTA provides new insights into chronic changes in dopamine signaling post-TBI, and the potential role of EE in TBI rehabilitation.
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