ArticleAllergy2012
IgE, but not IgG4, antibodies to Ara h 2 distinguish peanut allergy from asymptomatic peanut sensitization.
Article in Allergy, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.
- Genome-wide association study identifies peanut allergy-specific loci and evidence of epigenetic mediation in US children.Nature communications · 2015Pooled it
- Utility of component analyses in subjects undergoing sublingual immunotherapy for peanut allergy.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2016Trial
- Biomarker-driven drug development for allergic diseases and asthma: An FDA public workshop.The Journal of allergy and clinical immunology · 2025Article
- Developing a Prediction Model for Determination of Peanut Allergy Status in the Learning Early About Peanut Allergy (LEAP) Studies.The journal of allergy and clinical immunology. In practice · 2023Article
- Peanut components measured by ISAC: comparison with ImmunoCap and clinical relevance in peanut allergic children.Clinical and molecular allergy : CMA · 2021Article
- Current Controversies and Future Prospects for Peanut Allergy Prevention, Diagnosis and Therapies.Journal of asthma and allergy · 2020Review
- The diagnosis and management of food allergies. Position paper of the Food Allergy Section the Polish Society of Allergology.Postepy dermatologii i alergologii · 2017Article
- Food Allergy in South Africa.Current allergy and asthma reports · 2017Review
- Molecular allergy diagnostic tests: development and relevance in clinical practice.Allergologie select · 2017Review
- Utility of Specific IgE to Ara h 2 in Italian Allergic and Tolerant Children Sensitized to Peanut.International journal of molecular and cellular medicine · 2016Article
- Applications of Molecular Diagnostic Testing in Food Allergy.Current allergy and asthma reports · 2015Review
- Early Life Origins of Metabolic Syndrome: The Role of Environmental Toxicants.Current environmental health reports · 2014Article
- Peanut-specific IgE antibodies in asymptomatic Ghanaian children possibly caused by carbohydrate determinant cross-reactivity.The Journal of allergy and clinical immunology · 2013Article
- Peanut sensitization profiles in Italian children and adolescents with specific IgE to peanuts.BioMed research international · 2013Article
- IgE and IgG4 Repertoire in Asymptomatic HDM-Sensitized and HDM-Induced Allergic Rhinitis Patients.International archives of allergy and immunologyArticle
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundThere are no available clinical tests that can accurately predict peanut allergy (PA) and/or anaphylaxis. This study is aimed at evaluating whether the component-resolved diagnostic (CRD) IgE and IgG4 tests can (i) distinguish PA from asymptomatic peanut sensitization (PS) and (ii) differentiate anaphylactic from nonanaphylactic PA.
methodsThis study included 20 nonatopic controls, 58 asymptomatically peanut-sensitized children, 55 nonanaphylactic, and 53 anaphylactic PA cases from the Chicago Food Allergy Study. IgE and IgG4 to 103 allergens were measured using the ImmunoCAP ISAC technology and were compared among each group of children. The random forest test was applied to estimate each allergen's ability to predict PA and/or peanut anaphylaxis.
resultsPeanut allergy cases (with or without anaphylaxis) had significantly higher IgE reactivity to Ara h 1-3 (peanut allergens) and Gly m 5-6 (soy allergens) than asymptomatically sensitized children (P < 0.00001). Similar but more modest relationships were found for IgG4 to Ara h 2 (P < 0.01). IgE to Ara h 2 was the major contributor to accurate discrimination between PA and asymptomatic sensitization. With an optimal cutoff point of 0.65 ISU-E, it conferred 99.1% sensitivity, 98.3% specificity, and a 1.2% misclassification rate in the prediction of PA, which represented a higher discriminative accuracy than IgE to whole peanut extract (P = 0.008). However, none of the IgE and/or IgG4 tests could significantly differentiate peanut anaphylaxis from nonanaphylactic PA.
conclusionsIgE to Ara h 2 can efficiently differentiate clinical PA from asymptomatic PS, which may represent a major step forward in the diagnosis of PA.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.