Trial reportAlcoholism, clinical and experimental research2013
Effect of predictive cuing on response inhibition in children with heavy prenatal alcohol exposure.
Trial report in Alcoholism, clinical and experimental research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Research Review: Executive function deficits in fetal alcohol spectrum disorders and attention-deficit/hyperactivity disorder - a meta-analysis.Journal of child psychology and psychiatry, and allied disciplines · 2016Pooled it
- Executive Functioning in Children and Adolescents Prenatally Exposed to Alcohol: A Meta-Analytic Review.Neuropsychology review · 2015Pooled it
- Article
- Article
- Examining the effects of prenatal alcohol exposure on performance of the sustained attention to response task in children with an FASD.Human brain mapping · 2023Article
- High-resolution imaging in studies of alcohol effect on prenatal development.Advances in drug and alcohol research · 2023Article
- Fetal Alcohol Exposure Alters BOLD Activation Patterns in Brain Regions Mediating the Interpretation of Facial Affect.Alcoholism, clinical and experimental research · 2021Article
- Distinguishing vigilance decrement and low task demands from mind-wandering: A machine learning analysis of EEG.The European journal of neuroscience · 2020Article
- Impairment of the context preexposure facilitation effect in juvenile rats by neonatal alcohol exposure is associated with decreased Egr-1 mRNA expression in the prefrontal cortex.Behavioral neuroscience · 2018Article
- Sensorimotor network alterations in children and youth with prenatal alcohol exposure.Human brain mapping · 2018Article
- Preliminary Findings that a Targeted Intervention Leads to Altered Brain Function in Children with Fetal Alcohol Spectrum Disorder.Brain sciences · 2017Article
- Differential Recruitment of Brain Regions During Response Inhibition in Children Prenatally Exposed to Alcohol.Alcoholism, clinical and experimental research · 2017Article
- The Effects of Preresponse Cues on Inhibitory Control and Response Time in Adults With ADHD.Journal of attention disorders · 2016Article
- Anterior cingulate cortex surface area relates to behavioral inhibition in adolescents with and without heavy prenatal alcohol exposure.Behavioural brain research · 2015Article
- An fMRI study of behavioral response inhibition in adolescents with and without histories of heavy prenatal alcohol exposure.Behavioural brain research · 2015Article
- Sex-related differences in auditory processing in adolescents with fetal alcohol spectrum disorder: A magnetoencephalographic study.NeuroImage. Clinical · 2015Article
- Fetal Alcohol Spectrum Disorders: Recent Neuroimaging Findings.Current developmental disorders reports · 2014Article
- The Use of Functional Near-Infrared Spectroscopy to Differentiate Alcohol-Related Neurodevelopmental Impairment.Developmental neuropsychologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
backgroundHeavy prenatal exposure to alcohol leads to widespread cognitive deficits, including problems with attention and response inhibition. This study examined blood oxygen level-dependent response in children with and without histories of heavy prenatal alcohol exposure during a task of response inhibition consisting of cued and noncued trials.
methodsChildren and adolescents (ages 8 to 18 years) with (alcohol-exposed [AE] = 20) and without (control [CON] = 15) histories of heavy prenatal exposure to alcohol underwent functional magnetic resonance imaging while performing a go/no-go task. Unbeknownst to subjects, a predictive cue preceded the no-go stimulus in 87% of trials.
resultsGroups were matched on demographic variables and did not differ on most measures of task performance. However, following cued stimuli, the AE group demonstrated a lower hit rate to go stimuli and more conservative response bias than the CON group. AE participants demonstrated more activation during no-go trials (inhibition) relative to go trials in the left precuneus, cingulate gyrus, anterior cingulate, and right medial frontal gyrus. During cue-dependent response inhibition, the AE group demonstrated less activation in the left precentral and postcentral gyrus compared to the CON group.
conclusionsConsistent with previous studies of response inhibition, the AE group demonstrated greater frontal and parietal activation when attempting to inhibit prepotent responses than the CON group, despite similar rates of commission errors. This study further demonstrated that the AE group had impaired behavioral performance on cued trials and demonstrated less activation in precentral and postcentral gyri relative to the CON group on these trials. This investigation provides evidence of impaired behavioral and neural processing of sequential information in fetal alcohol spectrum disorders, which can help improve inhibition in typical populations.
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