ArticleThe journal of physical chemistry. B2012
A time-saving strategy for MAS NMR spectroscopy by combining nonuniform sampling and paramagnetic relaxation assisted condensed data collection.
Article in The journal of physical chemistry. B, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 38 citations in OpenAlex.
- Solid-State NMR Investigations of Extracellular Matrixes and Cell Walls of Algae, Bacteria, Fungi, and Plants.Chemical reviews · 2022Review
- Multivariate Curve Resolution for 2D Solid-State NMR spectra.Analytical chemistry · 2020Article
- Non-uniform sampling in quantitative assessment of heterogeneous solid-state NMR line shapes.Journal of biomolecular NMR · 2020Article
- Application of paramagnetic relaxation enhancements to accelerate the acquisition of 2D and 3D solid-state NMR spectra of oriented membrane proteins.Methods (San Diego, Calif.) · 2018Article
- New NMR tools for protein structure and function: Spin tags for dynamic nuclear polarization solid state NMR.Archives of biochemistry and biophysics · 2017Review
- Bacteriophage Tail-Tube Assembly Studied by Proton-Detected 4D Solid-State NMR.Angewandte Chemie (International ed. in English) · 2017Article
- GdJournal of biomolecular NMR · 2017Article
- Mapping protein-protein interactions by double-REDOR-filtered magic angle spinning NMR spectroscopy.Journal of biomolecular NMR · 2017Article
- Improving dipolar recoupling for site-specific structural and dynamics studies in biosolids NMR: windowed RN-symmetry sequences.Physical chemistry chemical physics : PCCP · 2016Article
- Experimental Protein Structure Verification by Scoring with a Single, Unassigned NMR Spectrum.Structure (London, England : 1993) · 2015Article
- Magic angle spinning NMR spectroscopy: a versatile technique for structural and dynamic analysis of solid-phase systems.Analytical chemistry · 2015Article
- MAS NMR of HIV-1 protein assemblies.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2015Article
- Magic angle spinning NMR of viruses.Progress in nuclear magnetic resonance spectroscopy · 2015Review
- Combined zero-quantum and spin-diffusion mixing for efficient homonuclear correlation spectroscopy under fast MAS: broadband recoupling and detection of long-range correlations.Journal of biomolecular NMR · 2015Article
- Fast magic angle spinning NMR with heteronucleus detection for resonance assignments and structural characterization of fully protonated proteins.Journal of biomolecular NMR · 2014Article
- Towards automatic protein backbone assignment using proton-detected 4D solid-state NMR data.Journal of biomolecular NMR · 2014Article
- Solid-state NMR structure determination from diagonal-compensated, sparsely nonuniform-sampled 4D proton-proton restraints.Journal of the American Chemical Society · 2014Article
- Sensitivity gains, linearity, and spectral reproducibility in nonuniformly sampled multidimensional MAS NMR spectra of high dynamic range.Journal of biomolecular NMR · 2014Article
- Time-resolved multidimensional NMR with non-uniform sampling.Journal of biomolecular NMR · 2014Article
- Paramagnetic doping of a 7TM membrane protein in lipid bilayers by Gd³⁺-complexes for solid-state NMR spectroscopy.Journal of biomolecular NMR · 2014Article
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
We present a time-saving strategy for acquiring 3D magic angle spinning NMR spectra for chemical shift assignments in proteins and protein assemblies in the solid state. By simultaneous application of nonuniform sampling (NUS) and paramagnetic-relaxation-assisted condensed data collection (PACC), we can attain 16-fold time reduction in the 3D experiments without sacrificing the signal-to-noise ratio or the resolution. We demonstrate that with appropriate concentration of paramagnetic dopant introduced into the sample the overwhelming majority of chemical shifts are not perturbed, with the exception of a limited number of shifts corresponding to residues located at the surface of the protein, which exhibit small perturbations. This approach enables multidimensional MAS spectroscopy in samples of intrinsically low sensitivity and/or high spectral congestion where traditional experiments fail, and is especially beneficial for structural and dynamics studies of large proteins and protein assemblies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.