ArticleScientific reports2012
Conserved and divergent elements in Torso RTK activation in Drosophila development.
Article in Scientific reports, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 42 citations in OpenAlex.
- Quantification of 20-Hydroxyecdysone FromBio-protocol · 2026Article
- Optogenetic control of transition to metamorphosis.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- TGFß/activin-dependent activation of Torso controls the timing of the metamorphic transition in the red flour beetle Tribolium castaneum.PLoS genetics · 2023Article
- iTRAQ Proteomic Analysis of Interactions Between 20E and Phospholipase C inFrontiers in physiology · 2022Article
- Transcriptome Profiling of the Pacific OysterMarine drugs · 2021Article
- A transitory signaling center controls timing of primordial germ cell differentiation.Developmental cell · 2021Article
- Neurotransmitters Affect Larval Development by Regulating the Activity of Prothoracicotropic Hormone-Releasing Neurons inFrontiers in neuroscience · 2021Article
- TheBiology open · 2019Article
- Hormonal signaling cascades required for phototaxis switch in wandering Leptinotarsa decemlineata larvae.PLoS genetics · 2019Article
- The trigger (and the restriction) of Torso RTK activation.Open biology · 2018Review
- Torso-Like Is a Component of the Hemolymph and Regulates the Insulin Signaling Pathway inGenetics · 2018Article
- Comparative RNA-sequencing analysis of ER-based HSP90 functions and signal pathways in Tribolium castaneum.Cell stress & chaperones · 2018Article
- Maternal Torso-Like Coordinates Tissue Folding DuringGenetics · 2017Article
- Transfer of Dorsoventral and Terminal Information from the Ovary to the Embryo by a Common Group of Eggshell Proteins inGenetics · 2017Article
- Reconstitution of Torso signaling in cultured cells suggests a role for both Trunk and Torso-like in receptor activation.Development (Cambridge, England) · 2017Article
- Development of the Cellular Immune System of Drosophila Requires the Membrane Attack Complex/Perforin-Like Protein Torso-Like.Genetics · 2016Article
- Torso-like mediates extracellular accumulation of Furin-cleaved Trunk to pattern the Drosophila embryo termini.Nature communications · 2015Article
- Transcriptional profiling of reproductive development, lipid storage and molting throughout the last juvenile stage of the marine copepod Calanus finmarchicus.Frontiers in zoology · 2014Article
- Torso-like functions independently of Torso to regulate Drosophila growth and developmental timing.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- The pea aphid uses a version of the terminal system during oviparous, but not viviparous, development.EvoDevo · 2013Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The repeated use of signalling pathways is a common phenomenon but little is known about how they become co-opted in different contexts. Here we examined this issue by analysing the activation of Drosophila Torso receptor in embryogenesis and in pupariation. While its putative ligand differs in each case, we show that Torso-like, but not other proteins required for Torso activation in embryogenesis, is also required for Torso activation in pupariation. In addition, we demonstrate that distinct enhancers control torso-like expression in both scenarios. We conclude that repeated Torso activation is linked to a duplication and differential expression of a ligand-encoding gene, the acquisition of distinct enhancers in the torso-like promoter and the recruitment of proteins independently required for embryogenesis. A combination of these mechanisms is likely to allow the repeated activation of a single receptor in different contexts.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.