ArticleJournal of gynecologic oncology2012
How low is low enough? Evaluation of various risk-assessment models for lymph node metastasis in endometrial cancer: a Korean multicenter study.
Article in Journal of gynecologic oncology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Predictive models for lymph node metastasis in endometrial cancer: A systematic review and bibliometric analysis.Women's health (London, England)Pooled it
- Article
- Clinical features related to lymphatic metastasis in grade 3 endometroid endometrial cancer: a retrospective cross-sectional study.Chinese medical journal · 2021Article
- MicroRNA expression profile in serum reveals novel diagnostic biomarkers for endometrial cancer.Bioscience reports · 2021Article
- Inadequately Staged Endometrial Cancer: a Clinical Dilemma.Indian journal of surgical oncology · 2018Article
- Article
- Comparing prediction models for lymph node metastasis risk in endometrial cancer: the winner may not take it all.Journal of gynecologic oncology · 2017Article
- Long-term outcomes of magnetic resonance imaging-invisible endometrial cancer.Journal of gynecologic oncology · 2016Article
- Preoperative tumor size at MRI predicts deep myometrial invasion, lymph node metastases, and patient outcome in endometrial carcinomas.International journal of gynecological cancer : official journal of the International Gynecological Cancer Society · 2015Article
- Expression of the ELAV-like protein HuR in the cytoplasm is associated with endometrial carcinoma progression.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Article
- Rictor is an independent prognostic factor for endometrial carcinoma.International journal of clinical and experimental pathology · 2014Article
- Aberrant microRNA expression in endometrial carcinoma using formalin-fixed paraffin-embedded (FFPE) tissues.PloS one · 2013Article
- Major clinical research advances in gynecologic cancer in 2012.Journal of gynecologic oncology · 2013Article
- Emerging concept of tailored lymphadenectomy in endometrial cancer.Journal of gynecologic oncology · 2012Article
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9 authors.
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Abstract
objectiveThe aim of this study was to identify a standard for the evaluation of future models for prediction of lymph node metastasis in endometrial cancer through estimation of performance of well-known surgicopathological models.
methodsUsing the medical records of 947 patients with endometrial cancer who underwent surgical management with lymphadenectomy, we retrospectively assessed the predictive performances of nodal metastasis of currently available models.
resultsWE EVALUATED THREE MODELS INCLUDED: 1) a model modified from the Gynecologic Oncology Group (GOG) pilot study; 2) one from the GOG-33 data; and 3) one from Mayo Clinic data. The three models showed similar negative predictive values ranging from 97.1% to 97.4%. Using Bayes' theorem, this can be translated into 2% of negative post-test probability when 10% of prevalence of lymph node metastasis was assumed. In addition, although the negative predictive value was similar among these models, the proportion that was classified as low-risk was significantly different between the studies (56.4%, 44.8%, and 30.5%, respectively; p<0.001).
conclusionThe current study suggests that a false negativity of 2% or less should be a goal for determining clinical usefulness of preoperative or intraoperative prediction models for low-risk of nodal metastasis.
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