ArticlePloS one2012
TTX-resistant NMDA receptor-mediated membrane potential oscillations in neonatal mouse Hb9 interneurons.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 20 citations in OpenAlex.
- Contributions of h- and NaFrontiers in cellular neuroscience · 2021Article
- The rhythm section: An update on spinal interneurons setting the beat for mammalian locomotion.Current opinion in physiology · 2019Article
- Premotor Neuron Divergence Reflects Vocal Evolution.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Sensory Activation of Command Cells for Locomotion and Modulatory Mechanisms: Lessons from Lampreys.Frontiers in neural circuits · 2016Review
- RNA interference of GluN1 inhibits neuronal rhythmogenesis in the adult inferior olive.Journal of molecular neuroscience : MN · 2015Article
- A synaptic mechanism for network synchrony.Frontiers in cellular neuroscience · 2014Review
- Dopamine: a parallel pathway for the modulation of spinal locomotor networks.Frontiers in neural circuits · 2014Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Conditional neuronal membrane potential oscillations have been identified as a potential mechanism to help support or generate rhythmogenesis in neural circuits. A genetically identified population of ventromedial interneurons, called Hb9, in the mouse spinal cord has been shown to generate TTX-resistant membrane potential oscillations in the presence of NMDA, serotonin and dopamine, but these oscillatory properties are not well characterized. Hb9 interneurons are rhythmically active during fictive locomotor-like behavior. In this study, we report that exogenous N-Methyl-D-Aspartic acid (NMDA) application is sufficient to produce membrane potential oscillations in Hb9 interneurons. In contrast, exogenous serotonin and dopamine application, alone or in combination, are not sufficient. The properties of NMDA-induced oscillations vary among the Hb9 interneuron population; their frequency and amplitude increase with increasing NMDA concentration. NMDA does not modulate the T-type calcium current (I(Ca(T))), which is thought to be important in generating locomotor-like activity, in Hb9 neurons. These results suggest that NMDA receptor activation is sufficient for the generation of TTX-resistant NMDA-induced membrane potential oscillations in Hb9 interneurons.
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