Trial reportPloS one2012
In-car nocturnal blue light exposure improves motorway driving: a randomized controlled trial.
Trial report in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01070004 (Countermeasures for Sleepiness at the Wheel and Prediction of Inter- Individual Differences to Their Responses), which is not on this map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Countermeasures for Sleepiness at the Wheel and Prediction of Inter- Individual Differences to Their Responses (KillSleep)
Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 63 citations in OpenAlex.
- The influence of blue light on sleep, performance and wellbeing in young adults: A systematic review.Frontiers in physiology · 2022Pooled it
- Effect of single caffeine intake on neuropsychological functions in healthy volunteers: A double-blind placebo-controlled study.PloS one · 2018Trial
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- Trial
- Gender Differences in Prevalence of Sleepy Driving Among Young Drivers in Saudi Arabia.Nature and science of sleep · 2024Article
- Neuroethical considerations and attitudes about neurostimulation as a fatigue countermeasure among emergency responders.Frontiers in neuroergonomics · 2024Article
- Effects of caffeine and blue-enriched light on spare visual attention during simulated space teleoperation.NPJ microgravity · 2023Article
- Effectiveness of caffeine and blue-enriched light on cognitive performance and electroencephalography correlates of alertness in a spaceflight robotics simulation.NPJ microgravity · 2023Article
- Relationship between Problematic Smartphone Use, Sleep Quality and Bedtime Procrastination: A Mediation Analysis.Behavioral sciences (Basel, Switzerland) · 2023Article
- Impact of Evening Light Exposures with Different Solid Angles on Circadian Melatonin Rhythms, Alertness, and Visual Comfort in an Automotive Setting.Clocks & sleep · 2022Article
- Acute sleep loss increases CNS health biomarkers and compromises the ability to stay awake in a sex-and weight-specific manner.Translational psychiatry · 2022Article
- A Neuroergonomics Approach to Mental Workload, Engagement and Human Performance.Frontiers in neuroscience · 2020Review
- Blue-Enriched Light Enhances Alertness but Impairs Accurate Performance in Evening Chronotypes Driving in the Morning.Frontiers in psychology · 2018Article
- Blue-Enriched White Light Enhances Physiological Arousal But Not Behavioral Performance during Simulated Driving at Early Night.Frontiers in psychology · 2017Article
- Color and psychological functioning: a review of theoretical and empirical work.Frontiers in psychology · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
unlabelledProlonged wakefulness greatly decreases nocturnal driving performance. The development of in-car countermeasures is a future challenge to prevent sleep-related accidents. The aim of this study is to determine whether continuous exposure to monochromatic light in the short wavelengths (blue light), placed on the dashboard, improves night-time driving performance. In this randomized, double-blind, placebo-controlled, cross-over study, 48 healthy male participants (aged 20-50 years) drove 400 km (250 miles) on motorway during night-time. They randomly and consecutively received either continuous blue light exposure (GOLite, Philips, 468 nm) during driving or 2*200 mg of caffeine or placebo of caffeine before and during the break. Treatments were separated by at least 1 week. The outcomes were number of inappropriate line crossings (ILC) and mean standard deviation of the lateral position (SDLP). Eight participants (17%) complained about dazzle during blue light exposure and were removed from the analysis. Results from the 40 remaining participants (mean age ± SD: 32.9±11.1) showed that countermeasures reduced the number of inappropriate line crossings (ILC) (F(2,91.11) = 6.64; p<0.05). Indeed, ILC were lower with coffee (12.51 [95% CI, 5.86 to 19.66], p = 0.001) and blue light (14.58 [CI, 8.75 to 22.58], p = 0.003) than with placebo (26.42 [CI, 19.90 to 33.71]). Similar results were found for SDLP. Treatments did not modify the quality, quantity and timing of 3 subsequent nocturnal sleep episodes. Despite a lesser tolerance, a non-inferior efficacy of continuous nocturnal blue light exposure compared with caffeine suggests that this in-car countermeasure, used occasionally, could be used to fight nocturnal sleepiness at the wheel in blue light-tolerant drivers, whatever their age. More studies are needed to determine the reproducibility of data and to verify if it can be generalized to women.
trial registrationClinicalTrials.gov NCT01070004.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.