ArticlePloS one2012
Recent emergence of Staphylococcus aureus clonal complex 398 in human blood cultures.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Contribution of the Oral and Gastrointestinal Microbiomes to Bloodstream Infections in Leukemia Patients.Microbiology spectrum · 2023Article
- TheGenes · 2021Review
- Clonality, virulence genes, and antibiotic resistance of Staphylococcus aureus isolated from blood in Shandong, China.BMC microbiology · 2021Article
- Methicillin-Resistant Staphylococci and Macrococci at the Interface of Human and Animal Health.Toxins · 2021Article
- Human Infection of Methicillin-SusceptibleMicroorganisms · 2020Review
- What can we learn from previous pandemics to reduce the frequency of emerging infectious diseases like COVID-19?Global transitions · 2020Article
- Increasing incidence of bloodstream infections due to Staphylococcus aureus clonal complex 398 in a French hospital between 2010 and 2017.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2019Article
- Temperate Prophages Increase Bacterial Adhesin Expression and Virulence in an Experimental Model of Endocarditis Due toFrontiers in microbiology · 2019Article
- Severe Disseminated Infection with Emerging Lineage of Methicillin-Sensitive Staphylococcus aureus.Emerging infectious diseases · 2019Article
- Comparative Secretome Analyses of Human and ZoonoticMolecular & cellular proteomics : MCP · 2018Article
- Whole-genome epidemiology, characterisation, and phylogenetic reconstruction of Staphylococcus aureus strains in a paediatric hospital.Genome medicine · 2018Article
- Article
- Prophages and adaptation of Staphylococcus aureus ST398 to the human clinic.BMC genomics · 2017Article
- Diffusion of clindamycin-resistant and erythromycin-resistant methicillin-susceptibleAntimicrobial resistance and infection control · 2017Article
- Human Infections with Staphylococcus aureus CC398.Current environmental health reports · 2015Review
- MRSA clonal complex 22 strains harboring toxic shock syndrome toxin (TSST-1) are endemic in the primary hospital in Gaza, Palestine.PloS one · 2015Article
- Prevalence of Staphylococcus aureus protein A (spa) mutants in the community and hospitals in Oxfordshire.BMC microbiology · 2014Article
- Emergence of a novel subpopulation of CC398 Staphylococcus aureus infecting animals is a serious hazard for humans.Frontiers in microbiology · 2014Article
- Livestock-associated MRSA carriage in patients without direct contact with livestock.PloS one · 2014Article
- Reply to Gandra et al.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2014Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRecently, a clone of MRSA with clonal complex 398 (CC398) has emerged that is related to an extensive reservoir in animals, especially pigs and veal calves. It has been reported previously that methicillin-susceptible variants of CC398 circulate among humans at low frequency, and these have been isolated in a few cases of bloodstream infections (BSI). The purpose of this study was to determine the prevalence of S. aureus CC398 in blood cultures taken from patients in a geographic area with a high density of pigs. METHODOLOGY/PRINCIPAL
findingsIn total, 612 consecutive episodes of S. aureus BSI diagnosed before and during the emergence of CC398 were included. Three strains (2 MSSA and 1 MRSA) that were isolated from bacteremic patients between 2010-2011 were positive in a CC398 specific PCR. There was a marked increase in prevalence of S. aureus CC398 BSI isolated between 2010-2011 compared to the combined collections that were isolated between 1996-1998 and 2002-2005 (3/157, 1.9% vs. 0/455, 0.0%; p = 0.017). CONCLUSIONS/SIGNIFICANCE: In conclusion, in an area with a relative high density of pigs, S. aureus CC398 was found as a cause of BSI in humans only recently. This indicates that S. aureus CC398 is able to cause invasive infections in humans and that the prevalence is rising. Careful monitoring of the evolution and epidemiology of S. aureus CC398 in animals and humans is therefore important.
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