ReviewExperimental diabetes research2012
Aspects of inflammation and oxidative stress in pediatric obesity and type 1 diabetes: an overview of ten years of studies.
Review in Experimental diabetes research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed.
- Exploring brain insulin resistance in adults with bipolar depression using extracellular vesicles of neuronal origin.Journal of psychiatric research · 2021Trial
- Obesity-Associated Cardiac Fibrosis: Mechanisms and Emerging Therapeutic Targets.Vascular health and risk management · 2026Review
- Distinct association patterns of chemokine profile and cardiometabolic status in children and adolescents with type 1 diabetes and obesity.Frontiers in endocrinology · 2024Article
- Obesity and atrial fibrillation: a narrative review from arrhythmogenic mechanisms to clinical significance.Cardiovascular diabetology · 2023Review
- Weight loss modifies lipid peroxidation and symmetric dimethylarginine levels in obese dogs.Canadian journal of veterinary research = Revue canadienne de recherche veterinaire · 2023Article
- Sex-Related Differences in Cardiovascular Disease Risk Profile in Children and Adolescents with Type 1 Diabetes.International journal of molecular sciences · 2021Review
- Participation of Hsp70 and Hsp90α Heat Shock Proteins in Stress Response in the Course of Type 1 Diabetes Mellitus.Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections · 2020Article
- Glutathione-dependent enzyme activities of peripheral blood mononuclear cells decrease during the winter season compared with the summer in normal-weight and severely obese adolescents.Journal of physiology and biochemistry · 2019Article
- Icariin prevents cytokine-induced β-cell death by inhibiting NF-κB signaling.Experimental and therapeutic medicine · 2018Article
- Iron status and its association with HbA1c levels in Dutch children with diabetes mellitus type 1.European journal of pediatrics · 2018Observational
- Traditional uses of medicinal plants to prevent and treat diabetes; an updated review of ethnobotanical studies in Iran.Journal of nephropathology · 2017Review
- The Impact of Environmental Factors in Influencing Epigenetics Related to Oxidative States in the Cardiovascular System.Oxidative medicine and cellular longevity · 2017Review
- Macrophage Migration Inhibitory Factor and Malondialdehyde as Potential Predictors of Vascular Risk Complications in Type 2 Diabetes Mellitus: Cross-Sectional Case Control Study in Saudi Arabia.Mediators of inflammation · 2016Article
- Diabetes mellitus and disturbances in brain connectivity: a bidirectional relationship?Neuromolecular medicine · 2014Review
- Epigallocatechin-3-gallate modulates anti-oxidant defense enzyme expression in murine submandibular and pancreatic exocrine gland cells and human HSG cells.Autoimmunity · 2014Article
- Macrophage migration inhibitory factor is overexpressed in pancreatic cancer tissues and impairs insulin secretion function of β-cell.Journal of translational medicine · 2014Article
- Body mass index and retinopathy in type 1 diabetic patients.International journal of endocrinology · 2014Article
- Obesity-associated oxidative stress: strategies finalized to improve redox state.International journal of molecular sciences · 2013Review
- Prooxidant-antioxidant balance in umbilical cord blood of infants with meconium stained of amniotic fluid.Biochemistry research international · 2013Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Obesity and type 1 diabetes (T1DM) are the two most common conditions of altered metabolism in children and adolescents. In both, similar long-term cardiovascular complications are known to occur, mediated in large part by underlying inflammatory and oxidative processes whose biochemical details remain relatively unclear. Through a series of experiments in these patient populations, over the last decade our laboratory has clarified a number of key issues in this field. Interestingly, while obese and type 1 diabetic children often differed in the specific type and magnitude of molecular alterations, in both groups a clear exaggeration of inflammatory and oxidative activation was detected when compared to healthy, age-matched controls. Our main findings include definition of resting and exercise-induced cytokine patterns and leukocyte profiles, patterns of activation of immune cells in vitro, and correlation of the magnitude of observed alterations with severity of obesity and quality of glycemic control. Further, we have identified a series of alterations in growth factor profiles during exercise that parallel inflammatory changes in obese children. This paper offers a concise overview of the salient results from this decade-long research effort.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.