ArticleJournal of biomedicine & biotechnology2012
The effect of bradykinin B2 receptor polymorphisms on the susceptibility and severity of osteoarthritis in a Chinese cohort.
Article in Journal of biomedicine & biotechnology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
7 citing papers in PubMed, 18 citations in OpenAlex.
- Injectable and Assembled Calcium Sulfate/Magnesium Silicate 3D Scaffold Promotes Bone Repair by In Situ Osteoinduction.Bioengineering (Basel, Switzerland) · 2025Article
- The single-nucleotide polymorphism (SNP) of tumor necrosis factor α -308G/A gene is associated with early-onset primary knee osteoarthritis in an Egyptian female population.Clinical rheumatology · 2017Article
- BDKRB2 +9/-9 bp polymorphisms influence BDKRB2 expression levels and NO production in knee osteoarthritis.Experimental biology and medicine (Maywood, N.J.) · 2017Article
- Photobiomodulation therapy in the modulation of inflammatory mediators and bradykinin receptors in an experimental model of acute osteoarthritis.Lasers in medical science · 2017Article
- Changes in Membrane Receptors and Ion Channels as Potential Biomarkers for Osteoarthritis.Frontiers in physiology · 2015Review
- Role of mtDNA haplogroups in the prevalence of knee osteoarthritis in a southern Chinese population.International journal of molecular sciences · 2014Article
- Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe B2-bradykinin receptor (BDKRB2) has been reported to associate with onset and development of Osteoarthritis (OA); however, the role of BDKRB2 genetic polymorphisms in OA remains unknown.
methodA total of 245 patients with primary knee OA and 264 healthy volunteer were recruited. BDKRB2 gene polymorphisms, -58T/C and +9/-9 bp polymorphisms, were genotyped.
resultsThe genotype distributions and allele frequencies of +9/-9 bp polymorphisms significantly differed between OA and control subjects. Logistic regression analysis showed carriers with -9/-9 genotype had a significantly increased risk for knee OA compared with the +9/+9 genotype (adjusted OR = 2.356, P < 0.001). The OR for -9 allele carriage was significantly higher than +9 allele carriage (adjusted OR = 1.52, P < 0.001). The +9/-9 bp polymorphisms also determined the OA radiographic severity. The presence of -9 bp was associated with severer OA. The -58T/C polymorphisms did not affect OA risk and severity.
conclusionThe +9/-9 bp polymorphisms of BDKRB2 gene may be used as a genetic marker for the susceptibility and severity of OA.
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Registered trials
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