ArticleProceedings of the National Academy of Sciences of the United States of America2012
Intrinsic reaction-cycle time scale of Na+,K+-ATPase manifests itself in the lipid-protein interactions of nonequilibrium membranes.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 40 citations in OpenAlex.
- Functional reconstitution of plant plasma membrane HScientific reports · 2025Article
- Active membrane deformations of a minimal synthetic cell.Nature physics · 2025Article
- Micromechanics of Biomembranes.The Journal of membrane biology · 2022Review
- En route to dynamic life processes by SNARE-mediated fusion of polymer and hybrid membranes.Nature communications · 2021Article
- Constructing artificial respiratory chain in polymer compartments: Insights into the interplay betweenProceedings of the National Academy of Sciences of the United States of America · 2020Article
- Coupled Response of Membrane Hydration with Oscillating Metabolism in Live Cells: An Alternative Way to Modulate Structural Aspects of Biological Membranes?Biomolecules · 2019Article
- Nonequilibrium fluctuations of lipid membranes by the rotating motor protein FProceedings of the National Academy of Sciences of the United States of America · 2017Article
- Bioinspired membrane-based systems for a physical approach of cell organization and dynamics: usefulness and limitations.Interface focus · 2015Review
- Direct Cytoskeleton Forces Cause Membrane Softening in Red Blood Cells.Biophysical journal · 2015Article
- Lipid directed intrinsic membrane protein segregation.Journal of the American Chemical Society · 2013Article
- Is the fluid mosaic (and the accompanying raft hypothesis) a suitable model to describe fundamental features of biological membranes? What may be missing?Frontiers in plant science · 2013Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
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Abstract
Interaction between integral membrane proteins and the lipid-bilayer component of biological membranes is expected to mutually influence the proteins and the membrane. We present quantitative evidence of a manifestation of the lipid-protein interactions in liposomal membranes, reconstituted with actively pumping Na(+),K(+)-ATPase, in terms of nonequilibrium shape fluctuations that contain a relaxation time, τ, which is robust and independent of the specific fluctuation modes of the membrane. In the case of pumping Na(+)-ions, analysis of the flicker-noise temporal correlation spectrum of the liposomes leads to τ ~/= 0.5 s, comparing favorably with an intrinsic reaction-cycle time of about 0.4 s from enzymology.
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