Evidence map›Paper›PMID 23093590›Full record

ArticleNucleic acids research2013

X-inactivation: quantitative predictions of protein interactions in the Xist network.

Federico Agostini, Davide Cirillo, Benedetta Bolognesi, Gian Gaetano Tartaglia

Abstract read
In one paragraph

Article in Nucleic acids research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
  5. A novel SATB1 protein isoform with different biophysical properties.Frontiers in cell and developmental biology · 2023
    Article
  6. Article
  7. Article
  8. Phase Separation Drives SARS-CoV-2 Replication: A Hypothesis.Frontiers in molecular biosciences · 2022
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Federico AgostiniCentre for Genomic Regulation, Dr Aiguader 88, 08003 Barcelona, Spain.
Davide Cirillo
Benedetta Bolognesi
Gian Gaetano Tartaglia

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The transcriptional silencing of one of the female X-chromosomes is a finely regulated process that requires accumulation in cis of the long non-coding RNA X-inactive-specific transcript (Xist) followed by a series of epigenetic modifications. Little is known about the molecular machinery regulating initiation and maintenance of chromosomal silencing. Here, we introduce a new version of our algorithm catRAPID to investigate Xist associations with a number of proteins involved in epigenetic regulation, nuclear scaffolding, transcription and splicing processes. Our method correctly identifies binding regions and affinities of protein interactions, providing a powerful theoretical framework for the study of X-chromosome inactivation and other events mediated by ribonucleoprotein associations.

Indexed as

AlgorithmsX Chromosome InactivationAnimalsBinding SitesEnhancer of Zeste Homolog 2 ProteinFemaleHeterogeneous-Nuclear Ribonucleoprotein UMatrix Attachment Region Binding ProteinsMiceNuclear ProteinsPolycomb Repressive Complex 2Repetitive Sequences, Nucleic AcidRNA-Binding ProteinsRNA, Long NoncodingSerine-Arginine Splicing FactorsYY1 Transcription FactorEnhancer of Zeste Homolog 2 ProteinEzh2 protein, mouseHeterogeneous-Nuclear Ribonucleoprotein UMatrix Attachment Region Binding ProteinsNuclear ProteinsPolycomb Repressive Complex 2RNA-Binding ProteinsRNA, Long NoncodingSAF-A protein, mouseSatb1 protein, mouseSerine-Arginine Splicing FactorsSuz12 protein, mouseXIST non-coding RNAYY1 Transcription Factor

Identifiers

PMID23093590
PMCPMC3592426

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.