Evidence map›Paper›PMID 23093573›Full record

ArticleCirculation research2013

Smooth muscle cell plasticity: fact or fiction?

Anh T Nguyen, Delphine Gomez, Robert D Bell, Julie H Campbell, Alexander W Clowes, Giulio Gabbiani, Cecilia M Giachelli, Michael S Parmacek, Elaine W Raines, Nancy J Rusch and 8 more

Abstract read
In one paragraph

Article in Circulation research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 100 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
100citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

100 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Extreme Diversity of the Human Vascular Mesenchymal Cell Landscape.Journal of the American Heart Association · 2020
    Pooled it
  3. Article
  4. Review
  5. Review
  6. Article
  7. Review
  8. MBNL loss of function in smooth muscle as a model for myotonic dystrophy associated gastrointestinal dysmotility.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  9. Review
  10. Article
  11. Article
  12. Biomaterials science · 2023
    Article
  13. Review
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review

40 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors.

Anh T NguyenUniversity of Virginia, Cardiovascular Research Center, Charlottesville, VA 22908, USA.
Delphine Gomez
Robert D Bell
Julie H Campbell
Alexander W Clowes
Giulio Gabbiani
Cecilia M Giachelli
Michael S Parmacek
Elaine W Raines
Nancy J Rusch
Mei Y Speer
Michael Sturek
Johan Thyberg
Dwight A Towler
Mary C Weiser-Evans
Chen Yan
Joseph M Miano
Gary K Owens

Funding

VIRAL VECTOR COREP30DK019525 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI MITCHELL A. LAZAR · 1986 to 2026
$48.3M
BASIC CARDIOVASCULAR RESEARCH TRAINING GRANTT32HL007284 · NHLBI · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI Brant E Isakson, Gary K Owens · 1985 to 2026
$19.6M
Vascular Calcification MechanismR01HL062329 · NHLBI · UNIVERSITY OF WASHINGTON · PI GIACHELLI, CECILIA M · 1999 to 2017
$5.3M
Calcification and Vascular Cell DifferentiationR01HL081785 · NHLBI · UNIVERSITY OF WASHINGTON · PI GIACHELLI, CECILIA M · 2005 to 2017
$3.7M
Role of OxPLs and Oct4 in SMC Phenotypic Switching in AtherosclerosisR01HL087867 · NHLBI · UNIVERSITY OF VIRGINIA · PI OWENS, GARY K · 2008 to 2016
$3.5M
Epigenetic Control of Smooth Muscle Cell Lineage and Phenotypic SwitchingR01HL057353 · NHLBI · UNIVERSITY OF VIRGINIA · PI OWENS, GARY K · 2008 to 2016
$3.5M
Role of IL1b in Regulating SMC and Macrophage Differentiation in AtherosclerosisR01HL121008 · NHLBI · UNIVERSITY OF VIRGINIA · PI OWENS, GARY K · 2014 to 2017
$2.2M
Myocardin Related Transcription Factor Function in the VasculatureR01HL102968 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI PARMACEK, MICHAEL S · 2010 to 2013
$1.8M
NHLBI NIH HHS R01 HL057353NHLBI NIH HHS R01 HL062329NHLBI NIH HHS R01 HL081785NHLBI NIH HHS R01 HL087867NHLBI NIH HHS R01 HL102968NHLBI NIH HHS R01 HL121008NHLBI NIH HHS T32 HL007284NIDDK NIH HHS P30 DK019525
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Cell DedifferentiationCell MovementCell ProliferationAnimalsCell LineageExtracellular MatrixGene Expression RegulationHumansMuscle, Smooth, VascularMyocytes, Smooth MusclePhenotypeSignal TransductionStem CellsVascular System InjuriesVasoconstriction

Identifiers

PMID23093573
PMCPMC4135725

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.