ArticleThe Journal of clinical endocrinology and metabolism2013
Association of female reproductive factors with body composition: the Framingham Heart Study.
Article in The Journal of clinical endocrinology and metabolism, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 2 of them syntheses that pooled it.
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Who cites it
53 citing papers in PubMed, 2 syntheses or guidelines pooled it, 96 citations in OpenAlex.
- Association of puberty timing with type 2 diabetes: A systematic review and meta-analysis.PLoS medicine · 2020Pooled it
- Nongenetic determinants of age at menarche: a systematic review.BioMed research international · 2014Pooled it
- Trial
- Review
- A Description of Temporal Trends and Age-Period-Cohort Effects in the Association Between Age at Menarche and Adult Obesity Among Women in the United States.Paediatric and perinatal epidemiology · 2026Article
- Adiposity and reproductive characteristics across the lifespan: a multi-ethnic population-based study in Northwest China.Reproductive health · 2026Article
- Age at menarche and general and abdominal obesity in older Brazilian women: ELSI-Brazil.Revista de saude publica · 2026Article
- Prevalence of dyslipidemia and associated factors among premenopausal and post-menopausal women: a community-based comparative cross-sectional study in Debre Markos city, Northwest, Ethiopia, 2024.BMC endocrine disorders · 2025Article
- Early Menarche and Hypertension Among Postmenopausal Women: The Mediating Role of Obesity.Epidemiologia (Basel, Switzerland) · 2025Article
- Association of age at menarche with type 2 diabetes mellitus among urban Indian women: results from the CARRS study.International journal of epidemiology · 2025Article
- Menopause and obstructive sleep apnea: revealing an independent mediating role of visceral fat beyond body mass index.BMC endocrine disorders · 2025Article
- Association of Female Reproductive Factors with Incident Cardiometabolic Disease: Finding from a European Population-Based Study.Global heart · 2025Article
- Association between lifetime endogenous estrogen exposure and body composition metrics in postmenopausal women: findings from the Tehran Lipid and Glucose Study.BMC women's health · 2024Article
- Association of Age at Menarche with General and Abdominal Obesity in Young Women.Medicina (Kaunas, Lithuania) · 2024Article
- The association between reproductive history and abdominal adipose tissue among postmenopausal women: results from the Women's Health Initiative.Human reproduction (Oxford, England) · 2024Article
- Association between age at menarche and cardiometabolic risk among Samoan adults.American journal of human biology : the official journal of the Human Biology Council · 2024Article
- WHAM-A Prospective Study of Weight and Body Composition After Risk-Reducing Bilateral Salpingo-oophorectomy.The Journal of clinical endocrinology and metabolism · 2023Observational
- Associations of age at first birth and lifetime parity with weight and adiposity across midlife in women from Project Viva.Obesity (Silver Spring, Md.) · 2023Article
- The relationship of reproductive factors with adiposity and body shape indices changes overtime: findings from a community-based study.Journal of translational medicine · 2023Article
- Age at Menarche Mediating Visceral Adipose Tissue's Influence on Pre-eclampsia: A Mendelian Randomization Study.The Journal of clinical endocrinology and metabolism · 2023Article
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Authors and funding
7 authors at 5 institutions in 1 country.
Funding
Abstract
backgroundIdentifying reproductive risk factors in women offers a life course approach to obesity and cardiovascular disease prevention. The association of female reproductive factors with measures of regional body fat distribution has not been comprehensively studied.
methodsWe examined the association of female reproductive factors (age at menarche, parity, age at natural menopause, menopausal status) in association with body composition data from women who participated in the Offspring and the Third Generation Framingham Heart Study cohorts. Visceral adipose tissue (VAT) and sc adipose tissue (SAT) were measured volumetrically by multidetector computerized tomography. We modeled the relationship between each fat depot and female reproductive factors after adjusting for various factors such as age, smoking status, alcohol intake, physical activity index, hormone replacement therapy, and menopausal status.
resultsEarlier age at menarche was associated with increased body mass index (BMI), waist circumference (WC), VAT, and SAT (P < 0.0001). This association of earlier menarche with adiposity measures was attenuated after adjusting for BMI (all P > 0.70). We observed no association between parity and all parameters of adiposity measurements (all P > 0.24). Similarly, age at natural menopause was not associated with measures of body composition. Despite higher mean BMI among the post- (BMI 27.3 kg/m(2)) compared with the premenopausal women (BMI 25.9 kg/m(2)) in an age-matched analysis, mean VAT was not different between the two groups (P = 0.30).
conclusionsEarlier menarche is associated with overall obesity but not with VAT or SAT after accounting for measures of generalized adiposity. Parity and menopausal age were not associated with adiposity measures. Although postmenopausal women had increased BMI, VAT, and SAT, the association was predominantly due to age.
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