ArticleDevelopment (Cambridge, England)2012
Gata2 provides an early anterior bias and uncovers a global positioning system for polarity in the amniote embryo.
Article in Development (Cambridge, England), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 33 citations in OpenAlex.
- RESEARCH NOTE: Effect of inhibition of bone morphogenetic protein signaling pathway by dorsomorphin on the establishment of embryo polarity.Poultry science · 2026Article
- Development and functions of the area opaca of the chick embryo.Developmental biology · 2025Review
- Regulation of long-range BMP gradients and embryonic polarity by propagation of local calcium-firing activity.Nature communications · 2024Article
- The evolution of gastrulation morphologies.Development (Cambridge, England) · 2023Review
- Reconstruction of distinct vertebrate gastrulation modes via modulation of key cell behaviors in the chick embryo.Science advances · 2023Article
- Exploring the roles of FGF/MAPK and cVG1/GDF signalling on mesendoderm induction and convergent extension during chick primitive streak formation.Development genes and evolution · 2022Article
- The extra-embryonic area opaca plays a role in positioning the primitive streak of the early chick embryo.Development (Cambridge, England) · 2022Article
- 'Neighbourhood watch' model: embryonic epiblast cells assess positional information in relation to their neighbours.Development (Cambridge, England) · 2022Article
- Vitrification of Pronuclear Zygotes Perturbs Porcine Zygotic Genome Activation.Animals : an open access journal from MDPI · 2022Article
- Disorders of Secondary Neurulation: Suggestion of a New Classification According to Pathoembryogenesis.Advances and technical standards in neurosurgery · 2022Article
- Caudal duplication syndrome: a literature review and reappraisal of its pathoembryogenesis.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2021Review
- Expression patterns of signalling molecules and transcription factors in the early rabbit embryo and their significance for modelling amniote axis formation.Development genes and evolution · 2021Article
- Disorders of Secondary Neurulation : Mainly Focused on Pathoembryogenesis.Journal of Korean Neurosurgical Society · 2021Article
- Cellular processes driving gastrulation in the avian embryo.Mechanisms of development · 2020Review
- Molecular anatomy of the pre-primitive-streak chick embryo.Open biology · 2020Article
- A molecular mechanism of symmetry breaking in the early chick embryo.Scientific reports · 2017Article
- Vertebrate Axial Patterning: From Egg to Asymmetry.Advances in experimental medicine and biology · 2017Review
- Germline development in amniotes: A paradigm shift in primordial germ cell specification.BioEssays : news and reviews in molecular, cellular and developmental biology · 2016Review
- Article
- Chick stem cells: current progress and future prospects.Stem cell research · 2013Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The first axis to be specified during vertebrate development is that between the site where gastrulation will begin and the opposite pole of the embryo (dorsoventral axis in amphibians and fish, anteroposterior in amniotes). This relies on Nodal activity, but different vertebrates differ in how this activity is positioned. In chick, the earliest known asymmetry is posterior expression of the TGFβ-related factor Vg1, close to the future Nodal expression domain. Here we show that the transcription factor Gata2 is expressed anteriorly before this stage. Gata2 influences the site of primitive streak formation and its role is independent from, and upstream of, Vg1 and Wnt. However, although Vg1 is required for streak formation, Gata2 does not act as an absolute anterior specifier, but provides an anterior bias. These findings point to previously unsuspected global determinants of polarity of the early amniote embryo.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.