ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2013
Nature or nurture? Determining the heritability of human striatal dopamine function: an [18F]-DOPA PET study.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- Chronic social stressors and striatal dopamine functioning in humans: A systematic review of SPECT and PET studies.Molecular psychiatry · 2024Pooled it
- Striatal Prediction Error Tracking Moderates the Influence of Social Exposure on Adolescent Substance Use Curiosity.Human brain mapping · 2026Article
- Striatal dopaminergic alterations in individuals with copy number variants at the 22q11.2 genetic locus and their implications for psychosis risk: a [18F]-DOPA PET study.Molecular psychiatry · 2023Article
- Internalizing-externalizing comorbidity and regional brain volumes in the ABCD study.Development and psychopathology · 2021Article
- The relationship between grey matter volume and striatal dopamine function in psychosis: a multimodalMolecular psychiatry · 2021Article
- The effects of psychosocial stress on dopaminergic function and the acute stress response.eLife · 2019Article
- DRD2 Genotype-Based Variants Modulates D2 Receptor Distribution in Ventral Striatum.Molecular neurobiology · 2019Article
- Inheritance of Neural Substrates for Motivation and Pleasure.Psychological science · 2019Article
- Brain neuroreceptor density and personality traits: towards dimensional biomarkers for psychiatric disorders.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2018Review
- Redefining the endophenotype concept to accommodate transdiagnostic vulnerabilities and etiological complexity.Biomarkers in medicine · 2017Article
- Like mother like daughter: putamen activation as a mechanism underlying intergenerational risk for depression.Social cognitive and affective neuroscience · 2017Article
- Prediction of Neurocognitive Deficits by Parkinsonian Motor Impairment in Schizophrenia: A Study in Neuroleptic-Naïve Subjects, Unaffected First-Degree Relatives and Healthy Controls From an Indigenous Population.Schizophrenia bulletin · 2016Article
- Common Variation in the DOPA Decarboxylase (DDC) Gene and Human Striatal DDC Activity In Vivo.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2016Article
- Contribution of non-genetic factors to dopamine and serotonin receptor availability in the adult human brain.Molecular psychiatry · 2016Article
- Striatal dopamine, reward, and decision making in schizophrenia.Dialogues in clinical neuroscience · 2016Review
- Glutamate and dopamine in schizophrenia: an update for the 21st century.Journal of psychopharmacology (Oxford, England) · 2015Review
- Pharmacogenetics of antipsychotic-induced movement disorders as a resource for better understanding Parkinson's disease modifier genes.Frontiers in neurology · 2015Review
- Schizophrenia: an integrated sociodevelopmental-cognitive model.Lancet (London, England) · 2014Review
- A synthesis of evidence on inhibitory control and auditory hallucinations based on the Research Domain Criteria (RDoC) framework.Frontiers in human neuroscience · 2014Article
- Ventral striatal dopamine synthesis capacity is associated with individual differences in behavioral disinhibition.Frontiers in behavioral neuroscience · 2014Article
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
Abstract
Striatal dopamine function is important for normal personality, cognitive processes and behavior, and abnormalities are linked to a number of neuropsychiatric disorders. However, no studies have examined the relative influence of genetic inheritance and environmental factors in determining striatal dopamine function. Using [18F]-DOPA positron emission tomography (PET), we sought to determine the heritability of presynaptic striatal dopamine function by comparing variability in uptake values in same sex monozygotic (MZ) twins to dizygotic (DZ) twins. Nine MZ and 10 DZ twin pairs underwent high-resolution [18F]-DOPA PET to assess presynaptic striatal dopamine function. Uptake values for the overall striatum and functional striatal subdivisions were determined by a Patlak analysis using a cerebellar reference region. Heritability, shared environmental effects and non-shared individual-specific effects were estimated using a region of interest (ROI) analysis and a confirmatory parametric analysis. Overall striatal heritability estimates from the ROI and parametric analyses were 0.44 and 0.33, respectively. We found a distinction between striatal heritability in the functional subdivisions, with the greatest heritability estimates occurring in the sensorimotor striatum and the greatest effect of individual-specific environmental factors in the limbic striatum. Our results indicate that variation in overall presynaptic striatal dopamine function is determined by a combination of genetic factors and individual-specific environmental factors, with familial environmental effects having no effect. These findings underline the importance of individual-specific environmental factors for striatal dopaminergic function, particularly in the limbic striatum, with implications for understanding neuropsychiatric disorders such as schizophrenia and addictions.
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