Evidence map›Paper›PMID 23093223›Full record

Trial reportNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2013

Feasibility, safety, and efficacy of the combination of D-serine and computerized cognitive retraining in schizophrenia: an international collaborative pilot study.

Deepak C D'Souza, Rajiv Radhakrishnan, Edward Perry, Savita Bhakta, Nagendra M Singh, Richa Yadav, Danielle Abi-Saab, Brian Pittman, Santosh K Chaturvedi, Mahendra P Sharma and 2 more

Open access · bronzeAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 7 pooled it
3.6field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 7 syntheses or guidelines pooled it, 77 citations in OpenAlex.

  1. Pooled it
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  5. Natural Medicines for Psychotic Disorders: A Systematic Review.The Journal of nervous and mental disease · 2018
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  19. Glutamatergic dysfunction in Schizophrenia.Translational psychiatry · 2022
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Deepak C D'SouzaDepartment of Psychiatry, Yale University School of Medicine, New Haven, CT 06516, USA. deepak.dsouza@yale.edu
Rajiv Radhakrishnan
Edward Perry
Savita Bhakta
Nagendra M Singh
Richa Yadav
Danielle Abi-Saab
Brian Pittman
Santosh K Chaturvedi
Mahendra P Sharma
Morris Bell
Chittaranjan Andrade
Yale University · USNational Institute of Mental Health and Neurosciences · INVA Connecticut Healthcare System · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The combination of pharmacotherapy and cognitive retraining (CRT) for the cognitive deficits of schizophrenia may be more efficacious than either approach alone, but this has not yet been tested. This study evaluated the feasibility, safety, tolerability, and efficacy of 12 weeks of D-serine, combined with CRT in the treatment of cognitive deficits in schizophrenia at two academic sites in parallel, in India and the United States. In a randomized, partial double-blind, placebo-controlled, parallel-group design, 104 schizophrenia subjects (US site=22, Indian site=82) were randomized to: (1) D-serine (30 mg/kg)+CRT (5 h/week), (2) D-serine+control CRT, (3) CRT+placebo D-serine, and (4) placebo+control CRT. Completion rates were 84 and 100% in the Indian and US samples, respectively. On various outcome measures of safety and tolerability, the interventions were well tolerated. D-Serine and CRT did not show any significant effect on the Global Cognitive Index, although both interventions showed differential site effects on individual test performance. CRT resulted in a significant improvement in Verbal Working Memory, and a trend toward improvement in Attention/Vigilance. This is the first study to demonstrating the feasibility, safety, and tolerability of combination pharmacotherapy and CRT in a multicenter international clinical trial. These preliminary findings provide support for future studies using higher doses of D-serine that have been shown to be efficacious or other pharmacotherapies, along with the newer cognitive remediation strategies that are individualized and that target basic information processing.

Indexed as

Cooperative BehaviorAdultCognitive Behavioral TherapyCombined Modality TherapyComputer-Assisted InstructionDouble-Blind MethodFeasibility StudiesFemaleHumansInternationalityMaleMiddle AgedPilot ProjectsSchizophreniaSerineTreatment OutcomeSerine

Identifiers

PMID23093223
PMCPMC3547200
OpenAlexW1966954626

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.