ArticleNature communications2012
The convergent evolution of defensive polyacetylenic fatty acid biosynthesis genes in soldier beetles.
Article in Nature communications, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 40 citations in OpenAlex.
- Terminal alkyne formation by a pyridoxal phosphate-dependent enzyme.Nature chemical biology · 2026Article
- Cyanogenic millipede genome illuminates convergent evolution of cyanogenesis-related enzymes.PLoS genetics · 2025Article
- Ultrastructure and Transcriptome Analysis of the Larval Integument in Solitary and Gregarious Phases ofInsects · 2025Article
- A Horizontally Transferred Plant Fatty Acid Desaturase Gene Steers Whitefly Reproduction.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Examination of gammarid transcriptomes reveals a widespread occurrence of key metabolic genes from epibiont bdelloid rotifers in freshwater species.Open biology · 2023Article
- Evolution of Linoleic Acid Biosynthesis Paved the Way for Ecological Success of Termites.Molecular biology and evolution · 2023Article
- Review
- Variation on a theme: the structures and biosynthesis of specialized fatty acid natural products in plants.The Plant journal : for cell and molecular biology · 2022Review
- Cryptic halogenation reactions in natural product biosynthesis.Natural product reports · 2021Review
- Biosynthesis of alkyne-containing natural products.RSC chemical biology · 2021Review
- Article
- The Desaturase Gene Family is Crucially Required for Fatty Acid Metabolism and Survival of the Brown Planthopper,International journal of molecular sciences · 2019Article
- Article
- Identification of Genes Encoding Enzymes Catalyzing the Early Steps of Carrot Polyacetylene Biosynthesis.Plant physiology · 2018Article
- De novo characterization of Phenacoccus solenopsis transcriptome and analysis of gene expression profiling during development and hormone biosynthesis.Scientific reports · 2018Article
- A fluorogenic screening platform enables directed evolution of an alkyne biosynthetic tool.Chemical communications (Cambridge, England) · 2016Article
- Bacterial Genome Mining of Enzymatic Tools for Alkyne Biosynthesis.ACS chemical biology · 2015Article
- De novo biosynthesis of terminal alkyne-labeled natural products.Nature chemical biology · 2015Article
- Biosynthesis: a terminal triple bond toolbox.Nature chemical biology · 2015Article
Corrections and comments
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Authors and funding
7 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The defensive and bioactive polyacetylenic fatty acid, 8Z-dihydromatricaria acid, is sequestered within a wide range of organisms, including plants, fungi and soldier beetles. The 8Z-dihydromatricaria acid is concentrated in the defence and accessory glands of soldier beetles to repel avian predators and protect eggs. In eukaryotes, acetylenic modifications of fatty acids are catalysed by acetylenases, which are desaturase-like enzymes that act on existing double bonds. Here we obtained acyl Coenzyme A-linked desaturases from soldier beetle RNA and functionally expressed them in yeast. We show that three genes were sufficient for the conversion of a common monounsaturated fatty acid, oleic acid, to the 18 carbon precursor of 8Z-dihydromatricaria acid, that is, 9Z,16Z-octadecadiene-12,14-diynoic acid. These are the first eukaryotic genes reported to produce conjugated polyacetylenic fatty acids. Phylogenetic analysis shows that the genes responsible for 8Z-dihydromatricaria acid synthesis in soldier beetles evolved de novo and independently of the acetylenases of plants and fungi.
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