ArticleNature communications2012
Similarities between protein folding and granular jamming.
Article in Nature communications, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- High time-resolved studies of stick-slip show similar dilatancy to fast and slow earthquakes.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Coherent X-ray Scattering Reveals Nanoscale Fluctuations in Hydrated Proteins.The journal of physical chemistry. B · 2023Article
- Membrane Protein Structure, Function, and Dynamics: a Perspective from Experiments and Theory.The Journal of membrane biology · 2015Review
- Dynamic Allostery of the Catabolite Activator Protein Revealed by Interatomic Forces.PLoS computational biology · 2015Article
- Article
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Authors and funding
2 authors.
Funding
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Abstract
Grains and glasses, widely different materials, arrest their motions upon decreasing temperature and external load, respectively, in common ways, leading to a universal jamming phase diagram conjecture. However, unified theories are lacking, mainly because of the disparate nature of the particle interactions. Here we demonstrate that folded proteins exhibit signatures common to both glassiness and jamming by using temperature- and force-unfolding molecular dynamics simulations. Upon folding, proteins develop a peak in the interatomic force distributions that falls on a universal curve with experimentally measured forces on jammed grains and droplets. Dynamical signatures are found as a dramatic slowdown of stress relaxation upon folding. Together with granular similarities, folding is tied not just to the jamming transition, but a more nuanced picture of anisotropy, preparation protocol and internal interactions emerges. Results have implications for designing stable polymers and can open avenues to link protein folding to jamming theory.
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Registered trials
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