Evidence map›Paper›PMID 23093136›Full record

Trial reportDiabetologia2013

Improved lifestyle and decreased diabetes risk over 13 years: long-term follow-up of the randomised Finnish Diabetes Prevention Study (DPS).

J Lindström, M Peltonen, J G Eriksson, P Ilanne-Parikka, S Aunola, S Keinänen-Kiukaanniemi, M Uusitupa, J Tuomilehto, Finnish Diabetes Prevention Study (DPS)

4 registry-linked trialsAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Diabetologia, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 265 papers, 25 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
265citing papers in PubMed, 25 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03609697 naunknown statusnot on this mapstarted 2018, after this paper: background citation

Effects of a Community-based Weight Loss Programme Targetting Chinese Overweight Adults With Pre-diabetes: A Randomized Controlled Trial

TypeinterventionalSponsorThe University of Hong KongRan2018 to 2024Enrolled180ConditionsPre-diabetesArmsgroup-based lifestyle intervention, Minimal intervention (SMS intervention)
NCT04099550 naunknown statusnot on this mapstarted 2019, after this paper: background citation

Effect of Real-time Continuous Glucose Monitoring System in Overweight or Obese Adults With Prediabetes

TypeinterventionalSponsorPusan National University HospitalRan2019 to 2021Enrolled30ConditionsContinuous Glucose Monitoring, Prediabetic State, ObesityArmsRT-CGM, SMBG
NCT04281069 completednot on this mapstarted 2019, after this paper: background citation

Diabetes Type 2 in the Eastern Region of Morocco , Towards an Evidence-based Multidisciplinary Lifestyle Approach in Diabetes Type 2

TypeobservationalSponsorUniversiteit AntwerpenRan2019 to 2022Enrolled821ConditionsQuality of Life, Diabetes Mellitus, Type 2, Adherence, Medication, Diet Habit
NCT04875780 naunknown statusnot on this mapstarted 2021, after this paper: background citation

Effects of a Smartphone-based Weight Loss Programme Targeting Chinese Overweight Adults With Pre-diabetes: A Randomized Controlled Trial

TypeinterventionalSponsorThe University of Hong KongRan2021 to 2024Enrolled282ConditionsPre-diabetesArmsDigital diabetes prevention app intervention, Digital weight loss tracking app intervention, Wait-list control (usual care)
3 · Its place in the literature

Who cites it

265 citing papers in PubMed, 25 syntheses or guidelines pooled it.

  1. Pooled it
  2. Guideline
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Guideline
  8. Pooled it
  9. Guideline
  10. Pooled it
  11. Pooled it
  12. Pooled it
  13. Pooled it
  14. Pooled it
  15. Pooled it
  16. Pooled it
  17. Pooled it
  18. Pooled it
  19. Pooled it
  20. Pooled it

205 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

J LindströmDiabetes Prevention Unit, Department of Chronic Disease Prevention, National Institute for Health and Welfare, Hellsinki, Finland. jaana.lindstrom@thl.fi
M Peltonen
J G Eriksson
P Ilanne-Parikka
S Aunola
S Keinänen-Kiukaanniemi
M Uusitupa
J Tuomilehto
Finnish Diabetes Prevention Study (DPS)

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aims/hypothesisThis study aimed to determine whether lifestyle intervention lasting for 4 years affected diabetes incidence, body weight, glycaemia or lifestyle over 13 years among individuals at high risk of type 2 diabetes.

methodsOverweight, middle-aged men (n = 172) and women (n = 350) with impaired glucose tolerance were randomised in 1993-1998 to an intensive lifestyle intervention group (n = 265), aiming at weight reduction, dietary modification and increased physical activity, or to a control group (n = 257) that received general lifestyle information. The primary outcome was a diagnosis of diabetes based on annual OGTTs. Secondary outcomes included changes in body weight, glycaemia, physical activity and diet. After active intervention (median 4 years, range 1-6 years), participants still free of diabetes and willing to continue their participation (200 in the intervention group and 166 in the control group) were further followed until diabetes diagnosis, dropout or the end of 2009, with a median total follow-up of 9 years and a time span of 13 years from baseline.

resultsDuring the total follow-up the adjusted HR for diabetes (intervention group vs control group) was 0.614 (95% CI 0.478, 0.789; p < 0.001). The corresponding HR during the post-intervention follow-up was 0.672 (95% CI 0.477, 0.947; p = 0.023). The former intervention group participants sustained lower absolute levels of body weight, fasting and 2 h plasma glucose and a healthier diet. Adherence to lifestyle changes during the intervention period predicted greater risk reduction during the total follow-up. CONCLUSIONS/

interpretationLifestyle intervention in people at high risk of type 2 diabetes induces sustaining lifestyle change and results in long-term prevention of progression to type 2 diabetes.

Indexed as

Life StyleAdultBlood GlucoseBody WeightDiabetes Mellitus, Type 2ExerciseFemaleHumansMaleMiddle AgedBlood Glucose

Identifiers

PMID23093136

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.