ArticleVirchows Archiv : an international journal of pathology2012
Colorectal carcinoma grading by quantifying poorly differentiated cell clusters is more reproducible and provides more robust prognostic information than conventional grading.
Article in Virchows Archiv : an international journal of pathology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed.
- Optimal Criteria for G3 (Poorly Differentiated) Stage II Colon Cancer: Prospective Validation in a Randomized Controlled Study (SACURA Trial).The American journal of surgical pathology · 2020Trial
- Interobserver variability of histopathological assessment in pT1 colorectal carcinoma.Histopathology · 2026Article
- Intratumoral and peritumoral radiomics of MRI predict pathological differentiation in patients with rectal cancer.Oncology letters · 2026Article
- Pure Well-differentiated Adenocarcinoma as a Safe Factor for Lymph Node Metastasis and Recurrence of T1 Colorectal Cancer.Journal of the anus, rectum and colon · 2025Article
- Evaluation of Applicability of Tumor Budding and Poorly Differentiated Clusters as Additional Prognostic Markers in Colorectal Cancers.South Asian journal of cancer · 2024Article
- Histopronostic factors in superficial colorectal adenocarcinomas treated by endoscopy: reproducibility and impact of immunohistochemistry and digital pathology.Virchows Archiv : an international journal of pathology · 2024Article
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- Grades of Poorly Differentiated Clusters are Associated with Lymph Node and the Tumour, Node and Metastasis Stages in Colorectal Carcinoma.The Malaysian journal of medical sciences : MJMS · 2023Article
- Colorectal Carcinomas: Searching for New Histological Parameters Associated with Lymph Node Metastases.Medicina (Kaunas, Lithuania) · 2023Article
- Tumor budding in gastric cancer.World journal of gastrointestinal surgery · 2023Review
- Prognostic Ability of Tumor Budding Outperforms Poorly Differentiated Clusters in Gastric Cancer.Cancers · 2022Article
- Poorly differentiated cluster grade-a vital predictor for lymph node metastasis and oncological outcomes in patients with T1 colorectal cancer: a retrospective study.BMC gastroenterology · 2022Article
- Role of one-step nucleic acid amplification in colorectal cancer lymph node metastases detection.World journal of gastroenterology · 2022Review
- Poorly differentiated clusters and tumor budding are important prognostic factors in colorectal carcinomas.Bosnian journal of basic medical sciences · 2022Article
- Grading of endocervical adenocarcinoma: a novel prognostic system based on tumor budding and cell cluster size.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2022Article
- Lymph Node Tumor Burden Correlates With Tumor Budding and Poorly Differentiated Clusters: A New Prognostic Factor in Colorectal Carcinoma?Clinical and translational gastroenterology · 2021Article
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- Primary Tumor Histology Affects Oncological Outcomes Independently of the Anatomical Extent of Disease in Colorectal Liver Metastasis.JMA journal · 2020Article
- Clinical Impact and Prognostic Role of KRAS/BRAF/PIK3CA Mutations in Stage I Colorectal Cancer.Disease markers · 2018Article
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6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The most widely used system to define the histological grade of colorectal carcinoma (CRC) is based on the degree of gland formation. This system suffers from significant interobserver variability which may limit its prognostic value and consequently better standardized criteria for the assessment of histological grading of CRC are needed. The present study aims to evaluate and to compare, in a cohort of postsurgical pTNM stage I CRC, conventional histological grading, and a novel grading system based on the number of poorly differentiated clusters of neoplastic cells, in terms of interobserver reproducibility, prognostic significance on progression-free survival, and association with other clinicopathological characteristics. Grading with both systems was performed by two pathologists independently and blinded to the clinicopathological data. Interobserver agreement was higher when grade was assessed by counting poorly differentiated clusters than by assessing the relative proportion of the glandular component. Contrary to conventional grading, the novel system provided significant prognostic information in terms of progression-free survival and was significantly associated with budding, invasive growth, lymphatic invasion, and occult nodal metastases of CRC. In conclusion, our findings suggest that a tumor grading system based on the number of poorly differentiated clusters is more reproducible and provides better prognostic stratification of pTNM stage I CRC patients than conventional grading.
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