ArticleTranslational psychiatry2012
Dopaminergic involvement during mental fatigue in health and cocaine addiction.
Article in Translational psychiatry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 5 syntheses or guidelines pooled it, 69 citations in OpenAlex.
- How to Tackle Mental Fatigue: A Systematic Review of Potential Countermeasures and Their Underlying Mechanisms.Sports medicine (Auckland, N.Z.) · 2022Pooled it
- Distinct patterns of prefrontal cortical disengagement during inhibitory control in addiction: A meta-analysis based on population characteristics.Neuroscience and biobehavioral reviews · 2021Pooled it
- Meta-analysis of aberrant post-error slowing in substance use disorder: implications for behavioral adaptation and self-control.The European journal of neuroscience · 2019Pooled it
- Neuroimaging Impaired Response Inhibition and Salience Attribution in Human Drug Addiction: A Systematic Review.Neuron · 2018Pooled it
- The Effects of Mental Fatigue on Physical Performance: A Systematic Review.Sports medicine (Auckland, N.Z.) · 2017Pooled it
- Mental fatigue does not affect static balance under both single and dual task conditions in young adults.Experimental brain research · 2023Trial
- Abnormal response to methylphenidate across multiple fMRI procedures in cocaine use disorder: feasibility study.Psychopharmacology · 2016Trial
- Effects of methylphenidate on resting-state functional connectivity of the mesocorticolimbic dopamine pathways in cocaine addiction.JAMA psychiatry · 2013Trial
- A Narrative Hypothesis: The Important Role of Gut Microbiota in the Modulation of Effort Tolerance in Endurance Athletes.Nutrients · 2025Review
- Article
- Adenosine AFrontiers in pharmacology · 2024Article
- Cognitive Alterations in Addictive Disorders: A Translational Approach.Biomedicines · 2023Review
- Dysfunction of basal ganglia functional connectivity associated with subjective and cognitive fatigue in multiple sclerosis.Frontiers in neuroscience · 2023Article
- The neurobiology of drug addiction: cross-species insights into the dysfunction and recovery of the prefrontal cortex.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Review
- Multimodal investigation of dopamine DNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021Article
- Cognitive Fatigue Effects on Physical Performance: The Role of Interoception.Sports medicine (Auckland, N.Z.) · 2020Article
- Article
- Transcutaneous Vagus Nerve Stimulation (tVNS) Enhances Response Selection During Sequential Action.Frontiers in psychology · 2018Article
- Joint Effects of Peer Presence and Fatigue on Risk and Reward Processing in Late Adolescence.Journal of youth and adolescence · 2017Article
- Sex differences in addiction.Dialogues in clinical neuroscience · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
Dopamine modulates executive function, including sustaining cognitive control during mental fatigue. Using event-related functional magnetic resonance imaging (fMRI) during the color-word Stroop task, we aimed to model mental fatigue with repeated task exposures in 33 cocaine abusers and 20 healthy controls. During such mental fatigue (indicated by increased errors, and decreased post-error slowing and dorsal anterior cingulate response to error as a function of time-on-task), healthy individuals showed increased activity in the dopaminergic midbrain to error. Cocaine abusers, characterized by disrupted dopamine neurotransmission, showed an opposite pattern of response. This midbrain fMRI activity with repetition was further correlated with objective indices of endogenous motivation in all subjects: a state measure (task reaction time) and a trait measure (dopamine D2 receptor availability in caudate, as revealed by positron emission tomography data collected in a subset of this sample, which directly points to a contribution of dopamine to these results). In a second sample of 14 cocaine abusers and 15 controls, administration of an indirect dopamine agonist, methylphenidate, reversed these midbrain responses in both groups, possibly indicating normalization of response in cocaine abusers because of restoration of dopamine signaling but degradation of response in healthy controls owing to excessive dopamine signaling. Together, these multimodal imaging findings suggest a novel involvement of the dopaminergic midbrain in sustaining motivation during fatigue. This region might provide a useful target for strengthening self-control and/or endogenous motivation in addiction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.