Trial reportClinical cancer research : an official journal of the American Association for Cancer Research2012
Adoptive transfer of autologous T cells improves T-cell repertoire diversity and long-term B-cell function in pediatric patients with neuroblastoma.
Trial report in Clinical cancer research : an official journal of the American Association for Cancer Research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 39 citations in OpenAlex.
- CD8Advances in experimental medicine and biology · 2024Review
- Distinct immune characteristics distinguish hereditary and idiopathic chronic pancreatitis.The Journal of clinical investigation · 2020Article
- Review
- Human CD19-Targeted Mouse T Cells Induce B Cell Aplasia and Toxicity in Human CD19 Transgenic Mice.Molecular therapy : the journal of the American Society of Gene Therapy · 2018Article
- Frequency and proliferative response of circulating invariant natural killer T cells in pediatric patients with malignant solid tumors.Pediatric surgery international · 2018Article
- T cell receptor repertoire usage in cancer as a surrogate marker for immune responses.Seminars in immunopathology · 2017Review
- Gene therapy as a potential tool for treating neuroblastoma-a focused review.Cancer gene therapy · 2016Review
- Improving therapy of chronic lymphocytic leukemia with chimeric antigen receptor T cells.Seminars in oncology · 2016Review
- Adoptive immunotherapy for acute leukemia: New insights in chimeric antigen receptors.World journal of stem cells · 2015Review
- Chimeric Antigen Receptor- and TCR-Modified T Cells Enter Main Street and Wall Street.Journal of immunology (Baltimore, Md. : 1950) · 2015Review
- Neuroblastoma Arginase Activity Creates an Immunosuppressive Microenvironment That Impairs Autologous and Engineered Immunity.Cancer research · 2015Article
- Comprehensive analysis of the T-cell receptor beta chain gene in rhesus monkey by high throughput sequencing.Scientific reports · 2015Article
- Cytokine-induced killer cells combined with dendritic cells inhibited liver cancer cells.International journal of clinical and experimental medicine · 2015Article
- Chimeric antigen receptor therapy for cancer.Annual review of medicine · 2014Review
- Review
- Trial Watch: Adoptive cell transfer for anticancer immunotherapy.Oncoimmunology · 2013Article
- Sequence analysis of T-cell repertoires in health and disease.Genome medicine · 2013Review
Corrections and comments
- Erratum issued
Authors and funding
11 authors at 3 institutions in 1 country.
Funding
Abstract
purposeChildren with high-risk neuroblastoma have a poor prognosis with chemotherapy alone, and hematopoietic stem cell transplantation offers improved survival. As a dose-escalation strategy, tandem transplants have been used, but are associated with persistent immunocompromise. This study evaluated the provision of an autologous costimulated, activated T-cell product to support immunologic function. EXPERIMENTAL
designNineteen subjects with high-risk neuroblastoma were enrolled in a pilot phase and 23 subjects were entered in to the randomized study. Immunologic reconstitution was defined by flow cytometric and functional assays. Next-generation sequencing was conducted to identify changes to the T-cell repertoire. Twenty-two patients were vaccinated to define effects on antibody responses.
resultsSubjects who received their autologous costimulated T-cell product on day 2 had significantly superior T-cell counts and T-cell proliferation compared with those who received T cells on day 90. Early administration of autologous T cells suppressed oligoclonality and enhanced repertoire diversity. The subjects who received the day 2 T-cell product also had better responses to the pneumococcal vaccine.
conclusionsThe infusion of activated T cells can improve immunologic function especially when given early after transplant. This study showed the benefit of providing cell therapies during periods of maximum lymphopenia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.