ArticleThe journal of histochemistry and cytochemistry : official journal of the Histochemistry Society2013
Identification of the protein target of myelin-binding ligands by immunohistochemistry and biochemical analyses.
Article in The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed.
- Sequential associations of myelin dysfunction with Aβ and Tau pathology in Alzheimer's disease: a dynamic myelin perturbation.Alzheimer's research & therapy · 2026Article
- Baseline Findings from Dual-Phase Amyloid PET Study in Newly Diagnosed Multiple Sclerosis: Exploring Its Potential as a Biomarker of Myelination and Neurodegeneration.Journal of personalized medicine · 2025Article
- A robotic system for automated chemical synthesis of therapeutic agents.Materials advances · 2024Article
- Florbetapir PET-assessed demyelination is associated with faster tau accumulation in an APOE ε4-dependent manner.European journal of nuclear medicine and molecular imaging · 2024Article
- A clinically relevant formulation for direct administration of nerve specific fluorophores to mitigate iatrogenic nerve injury.Biomaterials · 2022Article
- Positron emission tomography in multiple sclerosis - straight to the target.Nature reviews. Neurology · 2021Review
- Clinically translatable formulation strategies for systemic administration of nerve-specific probes.Advanced therapeutics · 2021Article
- Article
- Neuroimaging Correlates of Cognitive Dysfunction in Adults with Multiple Sclerosis.Brain sciences · 2021Review
- Cerebral amyloid angiopathy distribution in older people: A cautionary note.Alzheimer's & dementia (New York, N. Y.) · 2021Article
- Fluorescence Image-Guided Surgery - a Perspective on Contrast Agent Development.Proceedings of SPIE--the International Society for Optical Engineering · 2020Article
- [European journal of nuclear medicine and molecular imaging · 2020Article
- Repurposing radiotracers for myelin imaging: a study comparing 18F-florbetaben, 18F-florbetapir, 18F-flutemetamol,11C-MeDAS, and 11C-PiB.European journal of nuclear medicine and molecular imaging · 2020Article
- Exploring the heterogeneity of MS lesions using positron emission tomography: a reappraisal of their contribution to disability.Brain pathology (Zurich, Switzerland) · 2018Review
- Multimodal partial volume correction: Application to [Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2017Article
- Direct Administration of Nerve-Specific Contrast to Improve Nerve Sparing Radical Prostatectomy.Theranostics · 2017Article
- Axon and Myelin Morphology in Animal and Human Spinal Cord.Frontiers in neuroanatomy · 2017Review
- Imaging Central Nervous System Demyelination and Remyelination by Positron-Emission Tomography.Brain plasticity (Amsterdam, Netherlands) · 2016Review
- Dynamic Imaging of Individual Remyelination Profiles in Multiple Sclerosis.Annals of neurology · 2016Article
- Visualizing Oxazine 4 nerve-specific fluorescenceProceedings of SPIE--the International Society for Optical Engineering · 2016Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
The ability to visualize myelin is important in the diagnosis of demyelinating disorders and the detection of myelin-containing nerves during surgery. The development of myelin-selective imaging agents requires that a defined target for these agents be identified and that a robust assay against the target be developed to allow for assessment of structure-activity relationships. We describe an immunohistochemical analysis and a fluorescence polarization binding assay using purified myelin basic protein (MBP) that provides quantitative evidence that MBP is the molecular binding partner of previously described myelin-selective fluorescent dyes such as BMB, GE3082, and GE3111.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.