ArticleBone2013
Variations in nanomechanical properties and tissue composition within trabeculae from an ovine model of osteoporosis and treatment.
Article in Bone, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
28 citing papers in PubMed, 55 citations in OpenAlex.
- Microdamage in biological hard tissues and its repair mechanisms.Biomedical engineering online · 2025Review
- PTH treatment before cyclic joint loading improves cartilage health and attenuates load-induced osteoarthritis development in mice.Science advances · 2024Article
- Bone quality changes as measured by Raman and FTIR spectroscopy in primiparous cows with humeral fracture from New Zealand.Frontiers in veterinary science · 2023Article
- Medial tibial plateau sustaining higher physiological stress than the lateral plateau: based on 3D printing and finite element method.Biomedical engineering online · 2022Article
- Generalized Uncoupled Bone Remodeling Associated With Delayed Healing of Fatigue Fractures.JBMR plus · 2022Article
- Compositional assessment of bone by Raman spectroscopy.The Analyst · 2021Review
- Effects of Fatigue Damage on the Microscopic Modulus of Cortical Bone Using Nanoindentation.Materials (Basel, Switzerland) · 2021Article
- Analysis of Bone Microarchitectural Changes and Structural Damage in Sickle Cell Disease-Induced Avascular Necrosis Using Raman Spectroscopy: Is there potential for medical management?Sultan Qaboos University medical journal · 2021Article
- Article
- Sequential Treatment of Estrogen Deficient, Osteopenic Rats with Alendronate, Parathyroid Hormone (1-34), or Raloxifene Alters Cortical Bone Mineral and Matrix Composition.Calcified tissue international · 2020Article
- Preclinical and Translational Studies in Small Ruminants (Sheep and Goat) as Models for Osteoporosis Research.Current osteoporosis reports · 2018Review
- Bone morphogenetic protein signaling through ACVR1 and BMPR1A negatively regulates bone mass along with alterations in bone composition.Journal of structural biology · 2018Article
- Dynamic structure and composition of bone investigated by nanoscale infrared spectroscopy.PloS one · 2018Article
- Vibrational spectroscopic techniques to assess bone quality.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2017Review
- Article
- Material heterogeneity in cancellous bone promotes deformation recovery after mechanical failure.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Raloxifene improves skeletal properties in an animal model of cystic chronic kidney disease.Kidney international · 2016Article
- Article
- The Effect of Osteoporosis Treatments on Fatigue Properties of Cortical Bone Tissue.Bone reports · 2015Article
- Tissue-level remodeling simulations of cancellous bone capture effects of in vivo loading in a rabbit model.Journal of biomechanics · 2015Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
Osteoporosis and treatment may affect both composition and nanomechanical properties and their spatial distributions within the individual trabeculae of cancellous bone at length scales that cannot be captured by bulk measurements. This study utilized 25 mature adult ewes divided into 5 treatment groups. Four treatment groups were given a dietary model for human high-turnover osteoporosis, and two of these were treated with antiresorptive drugs, either zoledronate (ZOL) or raloxifene (RAL), to examine their effects on bulk tissue properties and nanoscale tissue composition and mechanical properties within trabeculae. Treatment effects were most pronounced at the nanoscale, where RAL increased indentation modulus and hardness throughout trabeculae by 10% relative to the osteoporosis model. In comparison, ZOL increased these properties exclusively at the surfaces of trabeculae (indentation modulus +12%, hardness +16%). Nanomechanical alterations correlated with changes in tissue mineralization, carbonate substitution, crystallinity, and aligned collagen. Despite only minimal changes in bulk tissue tBMD, the nanomechanical improvements within trabeculae with both treatments greatly improved the predicted theoretical bending stiffness of individual trabeculae when idealized as cylindrical struts. Hence, small tissue-level alterations in critical locations for resisting trabecular failure could account for some of the discrepancy between the large reductions in fracture risk and the only modest changes in BMD with antiresorptive treatments.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.