ArticleNanotoxicology2014
The antibacterial effects of silver, titanium dioxide and silica dioxide nanoparticles compared to the dental disinfectant chlorhexidine on Streptococcus mutans using a suite of bioassays.
Article in Nanotoxicology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 126 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
126 citing papers in PubMed, 1 synthesis or guideline pooled it, 488 citations in OpenAlex.
- Antimicrobial efficacy and bonding properties of orthodontic bonding systems enhanced with silver nanoparticles: a systematic review with meta-analysis.BMC oral health · 2024Pooled it
- Applications of Nanomaterials in Restorative Dentistry and Endodontics: A Narrative Review.Materials (Basel, Switzerland) · 2026Review
- Dynamically actuated reconfigurable topographical surface enables active control of implant-associated infections.bioRxiv : the preprint server for biology · 2026Article
- Antibacterial effects of silver and titanium dioxide nanoparticles-coated orthodontic arch wires: in vitro study.BMC oral health · 2026Article
- Green synthesis of TiO₂ nanoparticles using cyanobacterial phycobiliproteins for antibacterial and antioxidant toothpaste applications.BMC microbiology · 2026Article
- Synthesis and characterization of a new 2-iminothiolate-modified dimethacrylate monomer with potential dental applications.RSC advances · 2026Article
- Antibacterial and Bioregenerative Nanomaterials in Oral Health: From Material Design to Clinical Translation and Technological Trends.Journal of functional biomaterials · 2026Review
- Metal oxide nanoparticles: emerging stars in biomedical application.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2026Review
- Structural, optical, and magnetic characterization of Cu-Zn-Ni spinel ferrite nanoparticles with antibacterial potential.Scientific reports · 2026Article
- Usage of Silver Nanoparticles in Orthodontic Appliances.Materials (Basel, Switzerland) · 2025Review
- Effects of silver nanoparticle coating on peri-implant mucosa and microbiome.International journal of implant dentistry · 2025Article
- A Promising Material for Biomedicine and Food Production Based on a Polymethyl Methacrylate-like Resin with Silicon Dioxide Nanoparticles.Molecules (Basel, Switzerland) · 2025Article
- "Preparation and implantation of nanoparticles in tooth enamel using pulsed laser to improve its resistance to bacteria and enhance hardness: an in vitro study".Lasers in medical science · 2025Article
- Enhanced penetration and antibacterial efficacy of calcium hydroxide modified with titanium dioxide nanoparticles.Scientific reports · 2025Article
- Microwave assisted starch stabilized green synthesis of zinc oxide nanoparticles for antibacterial and photocatalytic applications.Scientific reports · 2025Article
- Characterization of Silver Nanoparticles Synthesized Using Hypericum perforatum L. and Their Effects on Staphylococcus aureus.Microscopy research and technique · 2025Article
- Application of Modified Natural Zeolite-Clinoptilolite for Bacterial Control in the Environment.Materials (Basel, Switzerland) · 2025Review
- The impact of biocorrosion and titanium ions release on peri-implantitis.Clinical oral investigations · 2025Review
- Review
- Synthesis and Antibacterial Evaluation of Chlorhexidine- and Triclosan-Impregnated Kaolinite Nanocomposites.Materials (Basel, Switzerland) · 2025Article
66 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Metal-containing nanomaterials have the potential to be used in dentistry for infection control, but little is known about their antibacterial properties. This study investigated the toxicity of silver (Ag), titanium dioxide and silica nanoparticles (NPs) against the oral pathogenic species of Streptococcus mutans, compared to the routine disinfectant, chlorhexidine. The bacteria were assessed using the minimum inhibitory concentration assay for growth, fluorescent staining for live/dead cells, and measurements of lactate. All the assays showed that Ag NPs had the strongest antibacterial activity of the NPs tested, with bacterial growth also being 25-fold lower than that in chlorhexidine. The survival rate of bacteria under the effect of 100 mg l(-1) Ag NPs in the media was 2% compared to 60% with chlorhexidine, while the lactate concentration was 0.6 and 4.0 mM, respectively. Silica and titanium dioxide NPs had limited effects. Dialysis experiments showed negligible silver dissolution. Overall, Ag NPs were the best disinfectant and performed better than chlorhexidine. Improvements to the MIC assay are suggested.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.