ArticleCase reports in gastrointestinal medicine2012
Duodenal histoplasmosis presenting with upper gastrointestinal bleeding in an AIDS patient.
Article in Case reports in gastrointestinal medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed, 15 citations in OpenAlex.
- An Unexpected Culprit: Fatal Gastrointestinal Hemorrhage due to Duodenal Histoplasmosis in a Patient With End-Stage Renal Disease.ACG case reports journal · 2025Article
- Gastrointestinal Histoplasmosis: A Descriptive Review, 2001-2021.Life (Basel, Switzerland) · 2023Review
- A Comprehensive Review of Infectious Granulomatous Diseases of the Gastrointestinal Tract.Gastroenterology research and practice · 2021Review
- Atypical Obstructive Pseudotumors in AIDS as the Initial Manifestation of Gastrointestinal Histoplasmosis.Cureus · 2020Article
- A case of gastrointestinal histoplasmosis with esophageal involvement.Clinical journal of gastroenterology · 2020Article
- PrimaryCase reports in gastrointestinal medicine · 2016Article
- Giemsa and Grocott in the recognition of Histoplasma capsulatum in blood smears.Asian Pacific journal of tropical biomedicine · 2013Article
- Miliary tuberculosis in an Indian lady: Looking beyond miliary tuberculosis.Lung India : official organ of Indian Chest SocietyArticle
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gastrointestinal histoplasmosis (GIH) is common in patients with disseminated disease but only rarely comes to clinical attention due to the lack of specific signs and symptoms. We report the unusual case of a 33-year-old Caucasian male with advanced AIDS who presented with upper GI bleeding from diffuse erosions throughout the duodenum. Biopsy of the lesions revealed small bowel mucosa with granulomatous inflammation and macrophages with small intracellular yeasts consistent with disseminated histoplasmosis. The patient demonstrated significant clinical improvement following a two-week course of liposomal amphotericin B. To our knowledge, this is the first case report of duodenal histoplasmosis leading to clinically significant bleeding, manifesting with worsening anemia and melanotic stools. Given our findings, we maintain that GIH should be considered on the differential diagnosis for GI bleeding in AIDS patients at risk, specifically those with advanced immunosuppression (i.e., CD4(+) cell counts <100 cells/mm(3)) who reside in endemic areas (Ohio or Mississippi river valleys) and/or have a prior history of histoplasmosis. For diagnostic evaluation, we recommend checking a urine Histoplasma quantitative antigen EIA as well as upper and/or lower endoscopy with biopsy. We recommend treatment with a two-week course of liposomal amphotericin B followed by indefinite itraconazole.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.