ArticlePloS one2012
In-vivo imaging of the Drosophila wing imaginal disc over time: novel insights on growth and boundary formation.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Article
- Ribosomopathy-associated mutations cause proteotoxic stress that is alleviated by TOR inhibition.Nature cell biology · 2021Article
- Long-term in vivo imaging of Drosophila larvae.Nature protocols · 2020Article
- Insect Transcription Factors: A Landscape of Their Structures and Biological Functions inInternational journal of molecular sciences · 2018Review
- On chip cryo-anesthesia of Drosophila larvae for high resolution in vivo imaging applications.Lab on a chip · 2017Article
- Differential Regulation of Cyclin E by Yorkie-Scalloped Signaling in Organ Development.G3 (Bethesda, Md.) · 2017Article
- Article
- Calcium spikes, waves and oscillations in a large, patterned epithelial tissue.Scientific reports · 2017Article
- An Unbiased Analysis of Candidate Mechanisms for the Regulation of Drosophila Wing Disc Growth.Scientific reports · 2016Article
- Disruption of the Cdc42/Par6/aPKC or Dlg/Scrib/Lgl Polarity Complex Promotes Epithelial Proliferation via Overlapping Mechanisms.PloS one · 2016Article
- Analysis of mitochondrial structure and function in the Drosophila larval musculature.Mitochondrion · 2016Review
- A fluorescent tagging approach in Drosophila reveals late endosomal trafficking of Notch and Sanpodo.The Journal of cell biology · 2014Article
- Sizing it up: the mechanical feedback hypothesis of organ growth regulation.Seminars in cell & developmental biology · 2014Review
- Article
- Article
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Authors and funding
3 authors.
Funding
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Abstract
In developmental biology, the sequence of gene induction and pattern formation is best studied over time as an organism develops. However, in the model system of Drosophila larvae this oftentimes proves difficult due to limitations in imaging capabilities. Using the larval wing imaginal disc, we show that both overall growth, as well as the creation of patterns such as the distinction between the anterior(A) and posterior(P) compartments and the dorsal(D) and ventral(V) compartments can be studied directly by imaging the wing disc as it develops inside a larva. Imaged larvae develop normally, as can be seen by the overall growth curve of the wing disc. Yet, the fact that we can follow the development of individual discs through time provides the opportunity to simultaneously assess individual variability. We for instance find that growth rates can vary greatly over time. In addition, we observe that mechanical forces act on the wing disc within the larva at times when there is an increase in growth rates. Moreover, we observe that A/P boundary formation follows the established sequence and a smooth boundary is present from the first larval instar on. The division of the wing disc into a dorsal and a ventral compartment, on the other hand, develops quite differently. Contrary to expectation, the specification of the dorsal compartment starts with only one or two cells in the second larval instar and a smooth boundary is not formed until the third larval instar.
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