ArticleFrontiers in integrative neuroscience2012
Monosynaptic functional connectivity in cerebral cortex during wakefulness and under graded levels of anesthesia.
Article in Frontiers in integrative neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 43 citations in OpenAlex.
- Deriving connectivity from spiking activity in detailed models of large-scale cortical microcircuits.iScience · 2026Article
- Windows to Consciousness: The Role of Fronto-Parietal Connectivity in Anesthesia-Induced Unconsciousness.Current neuropharmacology · 2026Review
- Correlated variability and its attentional modulation depend on anatomical connectivity.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Desflurane improves electrical activity of neurons and alleviates oxygen-glucose deprivation-induced neuronal injury by activating the Kcna1-dependent Kv1.1 channel.Experimental brain research · 2024Article
- Microstimulation reveals anesthetic state-dependent effective connectivity of neurons in cerebral cortex.Frontiers in neuroscience · 2024Article
- A neuron model with unbalanced synaptic weights explains the asymmetric effects of anaesthesia on the auditory cortex.PLoS biology · 2023Article
- Volitional Generation of Reproducible, Efficient Temporal Patterns.Brain sciences · 2022Article
- Modeling cortical synaptic effects of anesthesia and their cholinergic reversal.PLoS computational biology · 2022Article
- Slow waves form expanding, memory-rich mesostates steered by local excitability in fading anesthesia.iScience · 2022Article
- Rapid Cortical Adaptation and the Role of Thalamic Synchrony during Wakefulness.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Alzheimer's pathology causes impaired inhibitory connections and reactivation of spatial codes during spatial navigation.Cell reports · 2021Article
- State-Dependent Cortical Unit Activity Reflects Dynamic Brain State Transitions in Anesthesia.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Desflurane Anesthesia Alters Cortical Layer-specific Hierarchical Interactions in Rat Cerebral Cortex.Anesthesiology · 2020Article
- Understanding the Effects of General Anesthetics on Cortical Network Activity Using Ex Vivo Preparations.Anesthesiology · 2019Review
- Attention Enhances the Efficacy of Communication in V1 Local Circuits.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Neural Correlates of Unconsciousness in Large-Scale Brain Networks.Trends in neurosciences · 2018Review
- Removal of Perineuronal Nets Unlocks Juvenile Plasticity Through Network Mechanisms of Decreased Inhibition and Increased Gamma Activity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Repertoire of mesoscopic cortical activity is not reduced during anesthesia.Neuroscience · 2016Article
- Article
- Effects of GABAA kinetics on cortical population activity: computational studies and physiological confirmations.Journal of neurophysiology · 2016Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
The balance between excitation and inhibition is considered to be of significant importance for neural computation and cognitive function. Excitatory and inhibitory functional connectivity in intact cortical neuronal networks in wakefulness and graded levels of anesthesia has not been systematically investigated. We compared monosynaptic excitatory and inhibitory spike transmission probabilities using pairwise cross-correlogram (CCG) analysis. Spikes were measured at 64 sites in the visual cortex of rats with chronically implanted microelectrode arrays during wakefulness and three levels of anesthesia produced by desflurane. Anesthesia decreased the number of active units, the number of functional connections, and the strength of excitatory connections. Connection probability (number of connections per number of active unit pairs) was unaffected until the deepest anesthesia level, at which a significant increase in the excitatory to inhibitory ratio of connection probabilities was observed. The results suggest that the excitatory-inhibitory balance is altered at an anesthetic depth associated with unconsciousness.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.