ReviewInternational journal of biological sciences2012
Insights on FoxN1 biological significance and usages of the "nude" mouse in studies of T-lymphopoiesis.
Review in International journal of biological sciences, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
28 citing papers in PubMed, 52 citations in OpenAlex.
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- Mycobacteriophage-mediated gene transfer enables in vitro drug screening and in vivo tracking ofProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Recombinant FOXN1 fusion protein increases T cell generation in old mice.Frontiers in immunology · 2024Article
- A missense mutation in Lama3 causes androgen alopecia.Scientific reports · 2023Article
- Administration of recombinant FOXN1 protein attenuates Alzheimer's pathology in mice.Brain, behavior, and immunity · 2023Article
- MicroRNAs as the Critical Regulators of Forkhead Box Protein Family in Pancreatic, Thyroid, and Liver Cancers.Biochemical genetics · 2023Review
- CXCL12/CXCR4 Axis is Involved in the Recruitment of NK Cells by HMGB1 Contributing to Persistent Airway Inflammation and AHR During the Late Stage of RSV Infection.Journal of microbiology (Seoul, Korea) · 2023Article
- Effects of whole-brain radiation therapy on the blood-brain barrier in immunocompetent and immunocompromised mouse models.Radiation oncology (London, England) · 2023Article
- Development of the Nude Rabbit Model.Stem cell reports · 2021Article
- Thymus Degeneration and Regeneration.Frontiers in immunology · 2021Review
- Thymic rejuvenation via FOXN1-reprogrammed embryonic fibroblasts (FREFs) to counteract age-related inflammation.JCI insight · 2020Article
- Contributions of Age-Related Thymic Involution to Immunosenescence and Inflammaging.Immunity & ageing : I & A · 2020Review
- Targeted deletion of c-Met in thymic epithelial cells leads to an autoimmune phenotype.Immunology and cell biology · 2018Article
- FOXN1 Transcription Factor in Epithelial Growth and Wound Healing.Molecular and cellular biology · 2017Review
- T-cells contribute to hypertension but not to renal injury in mice with subtotal nephrectomy.BMC nephrology · 2017Article
- MicroRNAs as regulators and mediators of forkhead box transcription factors function in human cancers.Oncotarget · 2017Review
- Transplantation of Donor-Origin Mouse Embryonic Stem Cell-Derived Thymic Epithelial Progenitors Prevents the Development of Chronic Graft-versus-Host Disease in Mice.Stem cells translational medicine · 2017Article
- NK cells contribute to persistent airway inflammation and AHR during the later stage of RSV infection in mice.Medical microbiology and immunology · 2016Article
- Beneficial bacteria inhibit cachexia.Oncotarget · 2016Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Mutation in the "nude" gene, i.e. the FoxN1 gene, induces a hairless phenotype and a rudimentary thymus gland in mice (nude mouse) and humans (T-cell related primary immunodeficiency). Conventional FoxN1 gene knockout and transgenic mouse models have been generated for studies of FoxN1 gene function related to skin and immune diseases, and for cancer models. It appeared that FoxN1's role was fully understood and the nude mouse model was fully utilized. However, in recent years, with the development of inducible gene knockout/knockin mouse models with the loxP-Cre(ER(T)) and diphtheria toxin receptor-induced cell abolished systems, it appears that the complete repertoire of FoxN1's roles and deep-going usage of nude mouse model in immune function studies have just begun. Here we summarize the research progress made by several recent works studying the role of FoxN1 in the thymus and utilizing nude and "second (conditional) nude" mouse models for studies of T-cell development and function. We also raise questions and propose further consideration of FoxN1 functions and utilizing this mouse model for immune function studies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.