ArticleJournal of biomedicine & biotechnology2012
Attenuating effect of Ginkgo biloba leaves extract on liver fibrosis induced by thioacetamide in mice.
Article in Journal of biomedicine & biotechnology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 43 citations in OpenAlex.
- Hepatoprotective mechanisms of ginkgo-Biloba and dandelion extracts: antioxidant activity and modulation of TNF-α and P53 pathways in Thioacetamide-induced liver injury.Toxicology research · 2025Article
- Article
- Study of the effect of bezafibrate with ginkgo biloba extracts in an animal model of hepatotoxicity induced by doxorubicin.Biochemistry and biophysics reports · 2023Article
- Progress on traditional Chinese medicine in improving hepatic fibrosis through inhibiting oxidative stress.World journal of hepatology · 2023Review
- Article
- The potential protective influence of flaxseed oil against renal toxicity induced by thioacetamide in rats.Saudi journal of biological sciences · 2018Article
- Glibenclamide protects against thioacetamide-induced hepatic damage in Wistar rat: investigation on NLRP3, MMP-2, and stellate cell activation.Naunyn-Schmiedeberg's archives of pharmacology · 2018Article
- Ginkgo biloba extract (EGb761) did not express estrogenic activity in an immature rat uterotrophic assay.Environmental health and toxicology · 2018Article
- Preventive effects of total saponins ofArchives of medical science : AMS · 2018Article
- Chemoprotective effect of omega-3 fatty acids on thioacetamide induced hepatic fibrosis in male rats.Saudi journal of biological sciences · 2017Article
- Caffeine intake decreases oxidative stress and inflammatory biomarkers in experimental liver diseases induced by thioacetamide: Biochemical and histological study.International journal of immunopathology and pharmacology · 2017Article
- Effect of Olea oleaster and Juniperus procera leaves extracts on thioacetamide induced hepatic cirrhosis in male albino mice.Saudi journal of biological sciences · 2016Article
- Silymarin Protects Mouse Liver and Kidney from Thioacetamide Induced Toxicity by Scavenging Reactive Oxygen Species and Activating PI3K-Akt Pathway.Frontiers in pharmacology · 2016Article
- Influence of olive and rosemary leaves extracts on chemically induced liver cirrhosis in male rats.Saudi journal of biological sciences · 2015Article
- Ginkgo biloba extract mitigates liver fibrosis and apoptosis by regulating p38 MAPK, NF-κB/IκBα, and Bcl-2/Bax signaling.Drug design, development and therapy · 2015Article
- Article
- Physiological investigations on the effect of olive and rosemary leaves extracts in male rats exposed to thioacetamide.Saudi journal of biological sciences · 2014Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The purpose of this study is to investigate the effect of Ginkgo biloba leaves extract on experimental liver fibrosis induced by thioacetamide (TAA) in male albino mice. The experimental mice were divided into four groups. The mice of the first group were served as control. The experimental animals of the second group were given 150 mg/kg body weight of TAA by intraperitoneal injection, twice weekly, for 9 weeks. The mice of the third group were exposed to TAA and supplemented with G. biloba leaves extract. The animals of the fourth group were supplemented with G. biloba leaves extract. The levels of plasma alanine aminotransferase, aspartate aminotransferase, gamma-glutamyl transferase, alkaline phosphatase, triglycerides, cholesterol, and low-density lipoprotein cholesterol were statistically increased while the levels of plasma total protein, albumin, glucose, and high-density lipoprotein cholesterol were significantly decreased. The levels of liver superoxide dismutase, glutathione, glycogen and total protein were notably declined, whereas the level of total lipid was increased in mice of the second group. Furthermore, microscopic examination of liver sections from mice treated with TAA showed an abnormal morphology characterized by nodular transformations in liver parenchyma which surrounded by fibrous septa. Administration of G. biloba leaves extract reduced extent and development of fibrous septa, liver cells change, and biochemical alterations in mice exposed to TAA. This study showed that G. biloba leaves extract has a potential activity against TAA-induced liver fibrosis and suggested that the chemical constituents of G. biloba are effective in modulation of oxidative stress induced by TAA.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.