ArticleJournal of biomedicine & biotechnology2012
Frequency of TLR 2, 4, and 9 gene polymorphisms in Chinese population and their susceptibility to type 2 diabetes and coronary artery disease.
Article in Journal of biomedicine & biotechnology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 58 citations in OpenAlex.
- Association of polymorphisms in TLR3 and TLR7 genes with susceptibility to COVID-19 among Iranian population: a retrospective case-control study.Iranian journal of microbiology · 2024Article
- Article
- Investigation of TLR2 and TLR4 Polymorphisms and Sepsis Susceptibility: Computational and Experimental Approaches.International journal of molecular sciences · 2022Article
- Toll-like receptors in acute post-cataract surgery endophthalmitis.International ophthalmology · 2020Article
- TLR4 Polymorphisms (896A>G and 1196C>T) Affect the Predisposition to Diabetic Nephropathy in Type 2 Diabetes Mellitus.Diabetes, metabolic syndrome and obesity : targets and therapy · 2020Article
- Association of TLR3 single nucleotide polymorphisms with susceptibility to HTLV-1 infection in Iranian asymptomatic blood donors.Revista da Sociedade Brasileira de Medicina Tropical · 2020Article
- TIR-Domain-Containing Adaptor-Inducing Interferon-International journal of endocrinology · 2020Article
- Toll-like receptor 9 polymorphisms andWorld journal of gastrointestinal oncology · 2019Article
- Introducing tumor necrosis factor as a prominent player in celiac disease and type 1 diabetes mellitus.Gastroenterology and hepatology from bed to bench · 2019Article
- Polymorphisms within Genes Involved in Regulation of the NF-κB Pathway in Patients with Rheumatoid Arthritis.International journal of molecular sciences · 2017Article
- Toll-like receptors-2 and -9 (TLR2 and TLR9) gene polymorphism in patients with type 2 diabetes and diabetic foot.Medicine · 2017Observational
- Association of Toll-Like Receptor 3 and Toll-Like Receptor 9 Single Nucleotide Polymorphisms with Hepatitis C Virus Infection and Hepatic Fibrosis in Egyptian Patients.The American journal of tropical medicine and hygiene · 2017Article
- TLR-4 and CD14 Genotypes and Soluble CD14: Could They Predispose to Coronary Atherosclerosis?Journal of cardiovascular development and disease · 2016Article
- Toll-like receptor 2 and type 2 diabetes.Cellular & molecular biology letters · 2016Review
- Innate immunity in diabetes and diabetic nephropathy.Nature reviews. Nephrology · 2016Review
- Metainflammation in Diabetic Coronary Artery Disease: Emerging Role of Innate and Adaptive Immune Responses.Journal of diabetes research · 2016Review
- Genetic association of Toll-like receptor 4 gene and coronary artery disease in a Chinese Han population.SpringerPlus · 2016Article
- Toll-like receptor 4 gene polymorphisms and susceptibility to colorectal cancer: a meta-analysis and review.Archives of medical science : AMS · 2015Review
- Association of Toll-like receptor 2 polymorphisms with gout.Biomedical reports · 2014Article
- Evidences of +896 A/G TLR4 polymorphism as an indicative of prevalence of complications in T2DM patients.Mediators of inflammation · 2014Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Toll-like receptors (TLRs) are pivotal components of the innate immune response. Activation of the innate immune system and subsequent chronic low-grade inflammation are thought to be involved in the pathogenesis of atherosclerosis and type 2 diabetes. In the study, we genotyped TLRs gene polymorphisms, including TLR2 Arg677Trp and Arg753Gln, TLR4 Asp299Gly and Thr399Ile, TLR9-1486T/C and -1237T/C. The frequencies of TT, TC and CC genotype of TLR9-1486T/C mutation were 39.6%, 45.8% and 14.6%, respectively; the frequencies of T allele and C allele were 62.5% and 37.5%. However, neither of these parameters was statistically significant among study groups. In addition, we were surprised to find that the commonly reported TLR SNPs in the Western countries, like TLR2 Arg677Trp or Arg753Gln, TLR4 Asp299Gly or Thr399Ile and TLR9-1237T/C, were not polymorphic at all in all study subjects. In conclusion, our data suggests that TLR2 Arg677Trp or Arg753Gln, TLR4 Asp299Gly or Thr399Ile and TLR9-1237T/C polymorphisms have low frequency and TLR9-1486T/C polymorphism may not be a suitable marker in predicting the susceptibility to type 2 diabetes or coronary artery disease in the Chinese Han population.
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