ReviewMediators of inflammation2012
Does inflammation determine whether obesity is metabolically healthy or unhealthy? The aging perspective.
Review in Mediators of inflammation, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed, 1 synthesis or guideline pooled it, 97 citations in OpenAlex.
- Beyond BMI: The "Metabolically healthy obese" phenotype & its association with clinical/subclinical cardiovascular disease and all-cause mortality -- a systematic review.BMC public health · 2014Pooled it
- Review
- Is metabolically healthy obesity shaped by inflammation, gender differences, and fat distribution?World journal of cardiology · 2025Article
- Obesity in chronic spinal cord injury is associated with poorer body composition and increased risk of cardiometabolic disease.Scientific reports · 2025Article
- Correlation analysis of obesity phenotypes with leptin and adiponectin.Scientific reports · 2023Article
- Obesity during Pregnancy and SARS-CoV-2/COVID-19-Case Series of the Registry Study "COVID-19 Related Obstetric and Neonatal Outcome Study" (CRONOS-Network).Journal of clinical medicine · 2023Article
- The mediatory role of inflammatory markers on the relationship between the NOVA classification system and obesity phenotypes among obese and overweight adult women: a cross-sectional study.Frontiers in nutrition · 2023Article
- Association of Lifelines Diet Score (LLDS) and metabolically unhealthy overweight/obesity phenotypes in women: a cross-sectional study.BMC women's health · 2022Article
- Poor sleep and the metabolic derangements associated with obesity in adult males.Journal of family medicine and primary care · 2022Article
- Review
- Association of dietary phytochemical index with metabolically unhealthy overweight/obesity phenotype among Iranian women: A cross-sectional study.Frontiers in nutrition · 2022Article
- Establishment of triple-negative breast cancer cells based on BMI: A novel model in the correlation between obesity and breast cancer.Frontiers in oncology · 2022Article
- Metabolically healthy obesity: Inflammatory biomarkers and adipokines in elderly population.PloS one · 2022Article
- BMI, high-sensitivity C-reactive protein and the conversion from metabolically healthy to unhealthy phenotype in Chinese adults: a cohort study.Public health nutrition · 2021Article
- Leukocyte related parameters in older adults with metabolically healthy and unhealthy overweight or obesity.Scientific reports · 2021Article
- Obesity paradox and aging.Eating and weight disorders : EWD · 2021Review
- Article
- Obesity ‑ a risk factor for increased COVID‑19 prevalence, severity and lethality (Review).Molecular medicine reports · 2020Review
- Sociodemographic and metabolic risk characteristics associated with metabolic weight categories in the Women's Health Initiative.Cardiovascular endocrinology & metabolism · 2020Article
- Intake of dietary advanced glycation end products influences inflammatory markers, immune phenotypes, and antiradical capacity of healthy elderly in a little-studied population.Food science & nutrition · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Obesity is a major health issue in developed as well as developing countries. While obesity is associated with relatively good health status in some individuals, it may become a health issue for others. Obesity in the context of inflammation has been studied extensively. However, whether obesity in its various forms has the same adverse effects is a matter of debate and requires further research. During its natural history, metabolically healthy obesity (MHO) converts into metabolically unhealthy obesity (MUHO). What causes this transition to occur and what is the role of obesity-related mediators of inflammation during this transition is discussed in this paper.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.