New therapeutic targets in cardiology: arrhythmias and Ca2+/calmodulin-dependent kinase II (CaMKII).

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

65 citing papers in PubMed, 1 synthesis or guideline pooled it.

1. Brain-Heart Axis and Biomarkers of Cardiac Damage and Dysfunction after Stroke: A Systematic Review and Meta-Analysis.International journal of molecular sciences · 2020
   Pooled it
2. Arrhythmias, elicited by catecholamines and serotonin, vanish in human chronic atrial fibrillation.Proceedings of the National Academy of Sciences of the United States of America · 2014
   Trial
3. Understanding the Diseased Atria.Physiology (Bethesda, Md.) · 2026
   Review
4. Signal Recognition Granule Receptor Beta Subunit Promotes Arrhythmogenic Remodeling in the Heart Failure Mice.Journal of the American Heart Association · 2026
   Article
5. Aberrant myocardial calcium cycling: pathogenic mechanisms and targeted therapeutics for heart failure.Frontiers in cardiovascular medicine · 2026
   Review
6. Structural Integrity of RyR2 Clusters Controls Cardiac Calcium Leak.bioRxiv : the preprint server for biology · 2025
   Article
7. Importance of Zinc Homeostasis for Normal Cardiac Rhythm.Current cardiology reviews · 2025
   Review
8. Structural integrity of RyR2 clusters controls cardiac calcium leak.Frontiers in physiology · 2025
   Article
9. Mechanisms of torsades de pointes: an update.Frontiers in cardiovascular medicine · 2024
   Review
10. Calmodulin Mutations in Human Disease.Channels (Austin, Tex.) · 2023
    Review
11. Hydrogen sulfide-induced post-translational modification as a potential drug target.Genes & diseases · 2023
    Review
12. Gene expression patterns and related pathways in the hearts of rhesus monkeys subjected to prolonged myocardial ischemia.Experimental biology and medicine (Maywood, N.J.) · 2023
    Article
13. Calcium Signalling in Heart and Vessels: Role of Calmodulin and Downstream Calmodulin-Dependent Protein Kinases.International journal of molecular sciences · 2022
    Review
14. Rotors anchored by refractory islands drive torsades de pointes in an experimental model of electrical storm.Heart rhythm · 2022
    Article
15. Effects of Sacubitril/Valsartan on the Expression of CaMKII/CaBioMed research international · 2022
    Article
16. Stachydrine hydrochloride ameliorates cardiac hypertrophy through CaMKII/HDAC4/MEF2C signal pathway.American journal of translational research · 2022
    Article
17. Late sodium current and calcium homeostasis in arrhythmogenesis.Channels (Austin, Tex.) · 2021
    Review
18. Stress-driven cardiac calcium mishandling via a kinase-to-kinase crosstalk.Pflugers Archiv : European journal of physiology · 2021
    Review
19. GRKs and Epac1 Interaction in Cardiac Remodeling and Heart Failure.Cells · 2021
    Review
20. CaMKII in Regulation of Cell Death During Myocardial Reperfusion Injury.Frontiers in molecular biosciences · 2021
    Review

5 more citing papers are in PubMed but not listed here.

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

Authors and funding

2 authors.

Funding

Abstract

PubMed holds no abstract for this paper.

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