ArticleProceedings of the National Academy of Sciences of the United States of America2012
T-cell receptor (TCR) interaction with peptides that mimic nickel offers insight into nickel contact allergy.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.
- In Vitro Monitoring of Human T Cell Responses to Skin Sensitizing Chemicals-A Systematic Review.Cells · 2021Pooled it
- Article
- Updates in Metal Allergy: A Review of New Pathways of Sensitization, Exposure, and Treatment.Current allergy and asthma reports · 2025Review
- Transcriptome Analysis Reveals the Immunoregulatory Activity of Rice Seed-Derived Peptide PEP1 on Dendritic Cells.Molecules (Basel, Switzerland) · 2023Article
- Entropic analysis of antigen-specific CDR3 domains identifies essential binding motifs shared by CDR3s with different antigen specificities.Cell systems · 2023Article
- Chlorogenic Acid-Loaded Mesoporous Silica Nanoparticles Modified with Hexa-Histidine Peptides Reduce Skin Allergies by Capturing Nickel.Molecules (Basel, Switzerland) · 2022Article
- Editorial: Understanding and Engineering Antibody-Superantigen Interactions.Frontiers in immunology · 2022Article
- Immunological Mechanisms of Metal Allergies and the Nickel-Specific TCR-pMHC Interface.International journal of environmental research and public health · 2021Review
- The T Cell Repertoires from Nickel Sensitized Joint Implant Failure Patients.International journal of molecular sciences · 2021Article
- Lysosomal cathepsin creates chimeric epitopes for diabetogenic CD4 T cells via transpeptidation.The Journal of experimental medicine · 2021Article
- The Many Faces of CD4International journal of molecular sciences · 2020Review
- Impact of HLA-DR Antigen Binding Cleft Rigidity on T Cell Recognition.International journal of molecular sciences · 2020Article
- Ion Binding Properties of a Naturally Occurring Metalloantibody.Antibodies (Basel, Switzerland) · 2020Article
- Structural characteristics of lipocalin allergens: Crystal structure of the immunogenic dog allergen Can f 6.PloS one · 2019Article
- C-terminal modification of the insulin B:11-23 peptide creates superagonists in mouse and human type 1 diabetes.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Emerging Concepts in TCR Specificity: Rationalizing and (Maybe) Predicting Outcomes.Journal of immunology (Baltimore, Md. : 1950) · 2017Review
- Using DR52c/NiToxicology and applied pharmacology · 2017Article
- Immunoproteomic identification and characterization of NiCell death & disease · 2017Article
- Metal-specific CD4+ T-cell responses induced by beryllium exposure in HLA-DP2 transgenic mice.Mucosal immunology · 2016Article
- Beryllium-Induced Hypersensitivity: Genetic Susceptibility and Neoantigen Generation.Journal of immunology (Baltimore, Md. : 1950) · 2016Review
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
T cell-mediated allergy to Ni(++) is one of the most common forms of allergic contact dermatitis, but how the T-cell receptor (TCR) recognizes Ni(++) is unknown. We studied a TCR from an allergic patient that recognizes Ni(++) bound to the MHCII molecule DR52c containing an unknown self-peptide. We identified mimotope peptides that can replace both the self-peptide and Ni(++) in this ligand. They share a p7 lysine whose εNH(2) group is surface-exposed when bound to DR52c. Whereas the TCR uses germ-line complementary-determining region (CDR)1/2 amino acids to dock in the conventional diagonal mode on the mimotope-DR52c complex, the interface is dominated by the TCR Vβ CDR3 interaction with the p7 lysine. Mutations in the TCR CDR loops have similar effects on the T-cell response to either the mimotope or Ni(++) ligand. We suggest that the mimotope p7 lysine mimics Ni(++) in the natural TCR ligand and that MHCII β-chain flexibility in the area around the peptide p7 position forms a common site for cation binding in metal allergies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.