ArticleProceedings of the National Academy of Sciences of the United States of America2012
Structure of Sputnik, a virophage, at 3.5-Å resolution.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
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49 citing papers in PubMed, 87 citations in OpenAlex.
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- From parasites to partners: exploring the intricacies of host-transposon dynamics and coevolution.Functional & integrative genomics · 2023Review
- Near-atomic architecture of Singapore grouper iridovirus and implications for giant virus assembly.Nature communications · 2023Article
- Cryo-EM structure of ssDNA bacteriophage ΦCjT23 provides insight into early virus evolution.Nature communications · 2022Article
- Efficient Flexible Fitting Refinement with Automatic Error Fixing for De Novo Structure Modeling from Cryo-EM Density Maps.Journal of chemical information and modeling · 2021Article
- Molecular interactions of plant viral satellites.Virus genes · 2021Review
- Superimposition of Viral Protein Structures: A Means to Decipher the Phylogenies of Viruses.Viruses · 2020Review
- Surface stresses in complex viral capsids and non-quasi-equivalent viral architectures.Journal of the Royal Society, Interface · 2020Article
- Simulation-Based Methods for Model Building and Refinement in Cryoelectron Microscopy.Journal of chemical information and modeling · 2020Review
- Cryo-electron microscopy for the study of virus assembly.Nature chemical biology · 2020Review
- Virophages of Giant Viruses: An Update at Eleven.Viruses · 2019Review
- Viva lavidaviruses! Five features of virophages that parasitize giant DNA viruses.PLoS pathogens · 2019Article
- Near-atomic structure of a giant virus.Nature communications · 2019Article
- Implication for alphavirus host-cell entry and assembly indicated by a 3.5Å resolution cryo-EM structure.Nature communications · 2018Article
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
"Sputnik" is a dsDNA virus, referred to as a virophage, that is coassembled with Mimivirus in the host amoeba. We have used cryo-EM to produce an electron density map of the icosahedral Sputnik virus at 3.5-Å resolution, sufficient to verify the identity of most amino acids in the capsid proteins and to establish the identity of the pentameric protein forming the fivefold vertices. It was also shown that the virus lacks an internal membrane. The capsid is organized into a T = 27 lattice in which there are 260 trimeric capsomers and 12 pentameric capsomers. The trimeric capsomers consist of three double "jelly-roll" major capsid proteins creating pseudohexameric capsomer symmetry. The pentameric capsomers consist of five single jelly-roll proteins. The release of the genome by displacing one or more of the pentameric capsomers may be the result of a low-pH environment. These results suggest a mechanism of Sputnik DNA ejection that probably also occurs in other big icosahedral double jelly-roll viruses such as Adenovirus. In this study, the near-atomic resolution structure of a virus has been established where crystallization for X-ray crystallography was not feasible.
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