ArticleProceedings of the National Academy of Sciences of the United States of America2012
Capturing fleeting intermediates in a catalytic C-H amination reaction cycle.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Synthesis, characterization, and imidogen photochemistry of a hydrazoic acid adduct of RhChemical science · 2026Article
- Catalytic Amino Group Transfer Reactions Mediated by Photoinduced Nitrene Formation from Rhodium-Hydroxamates.Angewandte Chemie (International ed. in English) · 2025Article
- Development of Nonclassical Photoprecursors for RhInorganic chemistry · 2023Article
- RhJournal of the American Chemical Society · 2021Article
- Rhodium(ii)-catalyzed C-H aminations usingChemical science · 2019Article
- Collective Approach to Advancing C-H Functionalization.ACS central science · 2017Review
- Ambient ionization and miniature mass spectrometry system for chemical and biological analysis.Trends in analytical chemistry : TRAC · 2016Article
- Redox Non-Innocent Behavior of a Terminal Iridium Hydrazido(2-) Triple Bond.Angewandte Chemie (International ed. in English) · 2016Article
- Accurate quantification of creatinine in serum by coupling a measurement standard to extractive electrospray ionization mass spectrometry.Scientific reports · 2016Article
- Going beyond electrospray: mass spectrometric studies of chemical reactions in and on liquids.Chemical science · 2016Article
- Homolytic N-H activation of ammonia: hydrogen transfer of parent iridium ammine, amide, imide, and nitride species.Inorganic chemistry · 2015Article
- Multistage Reactive Transmission-Mode Desorption Electrospray Ionization Mass Spectrometry.Journal of the American Society for Mass Spectrometry · 2015Article
- Mechanism and Dynamics of Intramolecular C-H Insertion Reactions of 1-Aza-2-azoniaallene Salts.Journal of the American Chemical Society · 2015Article
- Mechanistic analysis of an asymmetric palladium-catalyzed conjugate addition of arylboronic acids to β-substituted cyclic enones.Chemical science · 2015Article
- Selective intermolecular amination of C-H bonds at tertiary carbon centers.Angewandte Chemie (International ed. in English) · 2013Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
We have applied an ambient ionization technique, desorption electrospray ionization MS, to identify transient reactive species of an archetypal C-H amination reaction catalyzed by a dirhodium tetracarboxylate complex. Using this analytical method, we have detected previously proposed short-lived reaction intermediates, including two nitrenoid complexes that differ in oxidation state. Our findings suggest that an Rh-nitrene oxidant can react with hydrocarbon substrates through a hydrogen atom abstraction pathway and raise the intriguing possibility that two catalytic C-H amination pathways may be operative in a typical bulk solution reaction. As highlighted by these results, desorption electrospray ionization MS should have broad applicability for the mechanistic study of catalytic processes.
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Registered trials
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