ArticleInfection and immunity2013
Schistosoma mansoni hemozoin modulates alternative activation of macrophages via specific suppression of Retnla expression and secretion.
Article in Infection and immunity, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 31 citations in OpenAlex.
- Article
- Immunological mechanisms involved in macrophage activation and polarization in schistosomiasis.Parasitology · 2023Review
- How to train your myeloid cells: a way forward for helminth vaccines?Frontiers in immunology · 2023Review
- Optimized Protocol for the Isolation of Extracellular Vesicles from the Parasitic WormJournal of immunology research · 2022Article
- A one-year unisexualFrontiers in immunology · 2022Article
- Dynamics of Host Immune Response Development DuringFrontiers in immunology · 2022Article
- Schistosome immunomodulators.PLoS pathogens · 2021Review
- The Role of Hypoxia-Induced Mitogenic Factor in Organ-Specific Inflammation in the Lung and Liver: Key Concepts and Gaps in Knowledge Regarding Molecular Mechanisms of Acute or Immune-Mediated Liver Injury.International journal of molecular sciences · 2021Review
- Revisiting the Mechanisms of Immune Evasion Employed by Human Parasites.Frontiers in cellular and infection microbiology · 2021Review
- Immune Evasion Strategies of Schistosomes.Frontiers in immunology · 2020Review
- Hemozoin From the Liver Fluke,Frontiers in veterinary science · 2019Article
- The anti-fecundity effect of 5-azacytidine (5-AzaC) on Schistosoma mansoni is linked to dis-regulated transcription, translation and stem cell activities.International journal for parasitology. Drugs and drug resistance · 2018Article
- Schistosome Egg Migration: Mechanisms, Pathogenesis and Host Immune Responses.Frontiers in immunology · 2018Review
- Single-sex infection with female Schistosoma mansoni cercariae mitigates hepatic fibrosis after secondary infection.PLoS neglected tropical diseases · 2017Article
- Clonorchis sinensis antigens alter hepatic macrophage polarization in vitro and in vivo.PLoS neglected tropical diseases · 2017Article
- Hemozoin "knobs" in Opisthorchis felineus infected liver.Parasites & vectors · 2015Article
- In Vivo MRI Assessment of Hepatic and Splenic Disease in a Murine Model of Schistosomiasis [corrected].PLoS neglected tropical diseases · 2015Article
- Temporal phenotypic features distinguish polarized macrophages in vitro.Autoimmunity · 2015Article
- Schistosome feeding and regurgitation.PLoS pathogens · 2014Review
- Excreted/secreted Schistosoma mansoni venom allergen-like 9 (SmVAL9) modulates host extracellular matrix remodelling gene expression.International journal for parasitology · 2014Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The trematode Schistosoma mansoni is one of the etiological agents of schistosomiasis, a key neglected tropical disease responsible for an estimated annual loss of 70 million disability-adjusted life years. Hematophagy represents the primary nutrient acquisition pathway of this parasite, but digestion of hemoglobin also liberates toxic heme. Schistosomes detoxify heme via crystallization into hemozoin, which is subsequently regurgitated into the host's circulation. Here we demonstrate that during experimental schistosomiasis, hemozoin accumulating in the mouse liver is taken up by phagocytes at a time coincident with the development of the egg-induced T-helper 2 (Th2) granulomatous immune response. Furthermore, the uptake of hemozoin also coincides with the hepatic expression of markers of alternative macrophage activation. Alternatively activated macrophages are a key effector cell population associated with protection against schistosomiasis, making hemozoin well placed to play an important immunomodulatory role in this disease. To systematically explore this hypothesis, S. mansoni hemozoin was purified and added to in vitro bone marrow-derived macrophage cultures concurrently exposed to cytokines chosen to reflect the shifting state of macrophage activation in vivo. Macrophages undergoing interleukin-4 (IL-4)-induced alternative activation in the presence of hemozoin developed a phenotype specifically lacking in Retnla, a characteristic alternatively activated macrophage product associated with regulation of Th2 inflammatory responses. As such, in addition to its important detoxification role during hematophagy, we propose that schistosome hemozoin also provides a potent immunomodulatory function in the coevolved network of host-parasite relationships during schistosomiasis.
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