ArticleInfection and immunity2013
A purified capsular polysaccharide markedly inhibits inflammatory response during endotoxic shock.
Article in Infection and immunity, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 34 citations in OpenAlex.
- Repositioning Antimicrobial Peptides Against WHO-Priority Fungi.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- The Capsular Polysaccharides GXM and GXMGal fromMicroorganisms · 2025Article
- Cryptococcosis Associated With Biologic Therapy: A Narrative Review.Open forum infectious diseases · 2024Review
- Intracellular Cryptococcus neoformans disrupts the transcriptome profile of M1- and M2-polarized host macrophages.PloS one · 2020Article
- The capsule ofVirulence · 2019Review
- Article
- Communication Between the Microbiota and Mammalian Immunity.Annual review of microbiology · 2018Review
- Variability in innate host immune responses to cryptococcosis.Memorias do Instituto Oswaldo Cruz · 2018Review
- The CSF Immune Response in HIV-1-Associated Cryptococcal Meningitis: Macrophage Activation, Correlates of Disease Severity, and Effect of Antiretroviral Therapy.Journal of acquired immune deficiency syndromes (1999) · 2017Article
- Article
- Sulfated Cyclocarya paliurus polysaccharides markedly attenuates inflammation and oxidative damage in lipopolysaccharide-treated macrophage cells and mice.Scientific reports · 2017Article
- The Cell Biology of theFrontiers in cellular and infection microbiology · 2017Review
- Modulation of Macrophage Inflammatory Nuclear Factor κB (NF-κB) Signaling by Intracellular Cryptococcus neoformans.The Journal of biological chemistry · 2016Article
- Cryptococcus: from environmental saprophyte to global pathogen.Nature reviews. Microbiology · 2016Review
- Cryptococcus inositol utilization modulates the host protective immune response during brain infection.Cell communication and signaling : CCS · 2014Article
- Cryptococcus neoformans copper detoxification machinery is critical for fungal virulence.Cell host & microbe · 2013Article
- Article
- Fungal extracellular vesicles: modulating host-pathogen interactions by both the fungus and the host.Microbes and infectionReview
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
Abstract
Capsular material of the opportunistic fungus Cryptococcus neoformans is composed mainly of a polysaccharide named glucuronoxylomannan (GXM). In this study, the effects of GXM were analyzed in an in vivo experimental system of lipopolysaccharide (LPS)-induced shock. Endotoxic shock was induced in mice by a single intraperitoneal injection of LPS from Escherichia coli. GXM treatment reduced the mortality of mice at early stages. Mice treated with LPS alone showed markedly increased plasma levels of tumor necrosis factor alpha (TNF-α), interleukin-1β (IL-1β), and IL-6, whereas mice that were also treated with GXM showed significantly lower plasma levels of these cytokines. This effect was related to a marked suppression of Akt and IκBα activation. Importantly, the inhibitory effect of GXM on proinflammatory cytokine secretion was reproduced by treatment with wortmannin, an inhibitor of the Akt transcription pathway. Our results indicate that GXM has a beneficial effect on endotoxic shock, resulting in a significant increase in the rate of survival by dampening the hyperinflammatory response.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.