ArticleJournal of materials science. Materials in medicine2013
Nanoparticles of cobalt-substituted hydroxyapatite in regeneration of mandibular osteoporotic bones.
Article in Journal of materials science. Materials in medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
29 citing papers in PubMed, 100 citations in OpenAlex.
- Role of the immune microenvironment in bone regeneration and progress in immune-modulating bone nanobiomaterials.Journal of Zhejiang University. Science. B · 2026Review
- Metal-Based Categorization of Recent Metal Organic Frameworks with Application in Bone Disease Treatment.ACS biomaterials science & engineering · 2025Review
- Manganese dioxide- and cobalt oxide-doped hydroxyapatite with curcumin for orthopedic and dental applications.Journal of materials research · 2025Article
- Advancements in Biomedical Applications of Calcium Phosphate Glass and Glass-Based Devices-A Review.Journal of functional biomaterials · 2024Review
- Bioremoval of Co(II) by a novel halotolerant microalgaeFrontiers in microbiology · 2024Article
- The Role of Trace Elements and Minerals in Osteoporosis: A Review of Epidemiological and Laboratory Findings.Biomolecules · 2023Review
- Recent Trends in Hydroxyapatite Supplementation for Osteoregenerative Purposes.Materials (Basel, Switzerland) · 2023Review
- Biocompatibility of nanomaterials and their immunological properties.Biomedical materials (Bristol, England) · 2021Review
- Nano-Based Biomaterials as Drug Delivery Systems Against Osteoporosis: A Systematic Review of Preclinical and Clinical Evidence.Nanomaterials (Basel, Switzerland) · 2021Review
- Biological Roles and Delivery Strategies for Ions to Promote Osteogenic Induction.Frontiers in cell and developmental biology · 2020Review
- Rare-earth (GdScientific reports · 2019Article
- Effects of hydroxyapatite@poly-lactide-Toxicology research · 2019Article
- The Effect of Electrode Topography on the Magnetic Properties and MRI Application of Electrochemically-Deposited, Synthesized, Cobalt-Substituted Hydroxyapatite.Nanomaterials (Basel, Switzerland) · 2019Article
- A Comparative Study on the Direct and Pulsed Current Electrodeposition of Cobalt-Substituted Hydroxyapatite for Magnetic Resonance Imaging Application.Materials (Basel, Switzerland) · 2018Article
- Traversing the profile of biomimetically nanoengineered iron substituted hydroxyapatite: synthesis, characterization, property evaluation, and drug release modeling.RSC advances · 2018Article
- Applications of Metals for Bone Regeneration.International journal of molecular sciences · 2018Review
- The deposition of strontium and zinc Co-substituted hydroxyapatite coatings.Journal of materials science. Materials in medicine · 2017Article
- One Ion to Rule Them All: Combined Antibacterial, Osteoinductive and Anticancer Properties of Selenite-Incorporated Hydroxyapatite.Journal of materials chemistry. B · 2017Article
- Calcium Phosphate as a Key Material for Socially Responsible Tissue Engineering.Materials (Basel, Switzerland) · 2016Article
- Advances in Nanotechnology for the Treatment of Osteoporosis.Current osteoporosis reports · 2016Review
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
Abstract
Indications exist that paramagnetic calcium phosphates may be able to promote regeneration of bone faster than their regular, diamagnetic counterparts. In this study, analyzed was the influence of paramagnetic cobalt-substituted hydroxyapatite nanoparticles on osteoporotic alveolar bone regeneration in rats. Simultaneously, biocompatibility of the material was tested in vitro, on osteoblastic MC3T3-E1 and epithelial Caco-2 cells in culture. The material was shown to be biocompatible and nontoxic when added to epithelial monolayers in vitro, while it caused a substantial decrease in the cell viability as well as deformation of the cytoskeleton and cell morphology when incubated with the osteoblastic cells. In the course of 6 months after the implantation of the material containing different amounts of cobalt, ranging from 5 to 12 wt%, in the osteoporotic alveolar bone of the lower jaw, the following parameters were investigated: histopathological parameters, alkaline phosphatase and alveolar bone density. The best result in terms of osteoporotic bone tissue regeneration was observed for hydroxyapatite nanoparticles with the largest content of cobalt ions. The histological analysis showed a high level of reparatory ability of the nanoparticulate material implanted in the bone defect, paralleled by a corresponding increase in the alveolar bone density. The combined effect of growth factors from autologous plasma admixed to cobalt-substituted hydroxyapatite was furthermore shown to have a crucial effect on the augmented osteoporotic bone regeneration upon the implantation of the biomaterial investigated in this study.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.