ArticlePlant molecular biology2013
Heme oxygenase-1 is involved in nitric oxide- and cGMP-induced α-Amy2/54 gene expression in GA-treated wheat aleurone layers.
Article in Plant molecular biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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23 citing papers in PubMed, 45 citations in OpenAlex.
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- A new plant guanosine cyclase ZjGC found from jujube regulates growth and development via endogenous hormones.Frontiers in plant science · 2025Article
- Benchmarking miRNA reference genes in B-cell precursor acute lymphoblastic leukemia.Scientific reports · 2024Article
- Cyclic guanosine monophosphate improves salt tolerance in Solanum lycopersicum.Journal of plant research · 2024Article
- Identification and validation of the optimal reference genes for standardizing the gene expression profiling diagnostic panel of Ph-like B-lineage acute lymphoblastic leukemia.Clinical and experimental medicine · 2023Article
- Nitrate-Nitrite-Nitric Oxide Pathway: A Mechanism of Hypoxia and Anoxia Tolerance in Plants.International journal of molecular sciences · 2022Review
- Identification and validation of suitable housekeeping genes for gene expression studies in BCR-ABL1 positive B-lineage acute lymphoblastic leukemia.Molecular biology reports · 2022Article
- Heme oxygenase-1/carbon monoxide signaling participates in the accumulation of triterpenoids ofJournal of Zhejiang University. Science. B · 2021Article
- Temperature and species-dependent regulation of browning in retrobulbar fat.Scientific reports · 2021Article
- Validation of reference genes for expression analysis in a murine trauma model combining traumatic brain injury and femoral fracture.Scientific reports · 2020Article
- Identification of housekeeping genes for microRNA expression analysis in kidney tissues of Pkd1 deficient mouse models.Scientific reports · 2020Article
- Dual Activities of Plant cGMP-Dependent Protein Kinase and Its Roles in Gibberellin Signaling and Salt Stress.The Plant cell · 2019Article
- Polyamines - A New Metabolic Switch: Crosstalk With Networks Involving Senescence, Crop Improvement, and Mammalian Cancer Therapy.Frontiers in plant science · 2019Article
- Exogenous Hydrogen Peroxide Contributes to Heme Oxygenase-1 Delaying Programmed Cell Death in Isolated Aleurone Layers of Rice Subjected to Drought Stress in a cGMP-Dependent Manner.Frontiers in plant science · 2018Article
- Osmopriming-induced salt tolerance during seed germination of alfalfa most likely mediates through HProtoplasma · 2017Article
- Involvement of secondary messengers and small organic molecules in auxin perception and signaling.Plant cell reports · 2015Review
- β-Cyclodextrin-hemin complex-induced lateral root formation in tomato: involvement of nitric oxide and heme oxygenase 1.Plant cell reports · 2015Article
- Cobalt alleviates GA-induced programmed cell death in wheat aleurone layers via the regulation of H2O2 production and heme oxygenase-1 expression.International journal of molecular sciences · 2014Article
- Heme oxygenase-1 is involved in sodium hydrosulfide-induced lateral root formation in tomato seedlings.Plant cell reports · 2014Article
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Authors and funding
7 authors at 1 institution in 1 country.
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Abstract
Here, α-Amy2/54 gene expression was used as a molecular probe to investigate the interrelationship among nitric oxide (NO), cyclic GMP (cGMP), and heme oxygenase-1 (HO-1) in GA-treated wheat aleurone layers. The inducible expressions of α-Amy2/54 and α-amylase activity were respectively amplified by two NO-releasing compounds, sodium nitroprusside (SNP) and spermine NONOate, in a GA-dependent fashion. Similar responses were observed when an inducer of HO-1, hemin-or one of its catalytic products, carbon monoxide (CO) in aqueous solution-was respectively added. The SNP-induced responses, mimicked by 8-bromoguanosine 3',5'-cyclic monophosphate (8-Br-cGMP), a cGMP derivative, were NO-dependent. This conclusion was supported by the fact that endogenous NO overproduction was rapidly induced by SNP, and thereafter induction of α-Amy2/54 gene expression and increased α-amylase activity were sensitive to the NO scavenger. We further observed that the above induction triggered by SNP and 8-Br-cGMP was partially prevented by zinc protoporphyrin IX (ZnPPIX), an inhibitor of HO-1. These blocking effects were clearly reversed by CO, confirming that the above response was HO-1-specific. Further analyses showed that both SNP and 8-Br-cGMP rapidly up-regulated HO-1 gene expression and increased HO activity, and SNP responses were sensitive to cPTIO and the guanylate cyclase inhibitor 6-anilino-5,8-quinolinedione (LY83583). Molecular evidence confirmed that GA-induced GAMYB and ABA-triggered PKABA1 transcripts were up-regulated or down-regulated by SNP, 8-Br-cGMP or CO cotreated with GA. Contrasting changes were observed when cPTIO, LY83583, or ZnPPIX was added. Together, our results suggested that HO-1 is involved in NO- and cGMP-induced α-Amy2/54 gene expression in GA-treated aleurone layers.
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