ArticleMetallomics : integrated biometal science2012
ZIP14 and ZIP8 zinc/bicarbonate symporters in Xenopus oocytes: characterization of metal uptake and inhibition.
Article in Metallomics : integrated biometal science, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 66 citations in OpenAlex.
- The SLC-ome of membrane transport: from molecular discovery to physiology and clinical applications.Physiological reviews · 2026Review
- Synergistic interaction between lead and cadmium via metal-transporter gene upregulation in mice.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2026Article
- Bioaccumulation Dynamics of Metal Ions and Complexes by Aquatic Organisms: An Extended Best and Michaelis-Menten Framework for the Interplay between Chemodynamics, Bioavailability, and Biouptake Kinetics.ACS environmental Au · 2026Article
- Cadmium Uptake into Rat Osteoblast UMR-106 Cells is Mediated via Multiple Pathways.Biological trace element research · 2026Article
- A homology-based 3D model and structure-function studies reveal key elements for divalent metal ion transporter ZIP8 (SLC39A8) function.The Journal of biological chemistry · 2025Article
- Removal of Toxic Metabolites-Chelation: Manganese Disorders.Journal of inherited metabolic disease · 2025Review
- Evolution, classification, and mechanisms of transport, activity regulation, and substrate specificity of ZIP metal transporters.Critical reviews in biochemistry and molecular biology · 2024Review
- Research progress on the molecular structure, function, and application in tumor therapy of zinc transporter ZIP4.International journal of biological sciences · 2024Review
- Iron Deficiency and Nephrotoxic Heavy Metals: A Dangerous Interplay?International journal of molecular sciences · 2023Review
- Cell-based transport assay to study kinetics and substrate specificity of human ZIPs.Methods in enzymology · 2023Article
- Manganese Pollution and Its Remediation: A Review of Biological Removal and Promising Combination Strategies.Microorganisms · 2022Review
- Review
- The Allelic Variant A391T of Metal Ion Transporter ZIP8 (SLC39A8) Leads to Hypotension and Enhanced Insulin Resistance.Frontiers in physiology · 2022Article
- Generation of a Polyclonal Antibody against the Mouse Metal Transporter ZIP8.Antibodies (Basel, Switzerland) · 2021Article
- A holistic view of mammalian (vertebrate) cellular iron uptake.Metallomics : integrated biometal science · 2020Review
- Effect of Oral Supplementation of Healthy Pregnant Sows with Sucrosomial Ferric Pyrophosphate on Maternal Iron Status and Hepatic Iron Stores in Newborn Piglets.Animals : an open access journal from MDPI · 2020Article
- The Functions of ZIP8, ZIP14, and ZnT10 in the Regulation of Systemic Manganese Homeostasis.International journal of molecular sciences · 2020Review
- Transcription factors and transporters in zinc homeostasis: lessons learned from fungi.Critical reviews in biochemistry and molecular biology · 2020Review
- Binding of Pb-Melatonin and Pb-(Melatonin-metabolites) complexes with DMT1 and ZIP8: implications for lead detoxification.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2019Article
- In utero gene expression in the Slc39a8(neo/neo) knockdown mouse.Scientific reports · 2018Article
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
The highly conserved human and mouse SLC39A14 and SLC39A8 genes encode the ZIP14 and ZIP8 transporters, respectively-functioning as divalent cation/bicarbonate symporters and expressed in dozens of tissues. Due to alternative splicing of exons 4, human and mouse SLC39A14 genes each encode two distinct gene products, whereas SLC39A8 produces a single product. This lab previously noted that ZIP14A and ZIP14B show highly variable expression in different cell types, suggesting differences in metal uptake function. We ligated mouse ZIP14A, ZIP14B and ZIP8 cDNA coding regions into the Xenopus-specific vector pXFRM, transcribed these in vitro, and microinjected the capped RNAs into Xenopus oocytes. K(m) and V(max) values for Cd, Zn and Fe uptake were determined. Electrogenicity studies using a potassium gradient confirmed that (just as we found previously for ZIP8) ZIP14A- and ZIP14B-mediated divalent Cd- or Zn-bicarbonate complexes are electroneutral. Competitive inhibition of Cd and Zn uptake with ten additional divalent cations showed a unique gradient of patterns for each of ZIP14A, ZIP14B and ZIP8. ZIP14 proteins are prominent in the gastrointestinal tract and ZIP8 protein is located on the surface of renal proximal tubular epithelial cells. It is known that renal Fanconi syndrome can be caused by five nonessential heavy metals: Cd(2+), Hg(2+), Pb(2+), Pt(2+) and U(2+). In the present study we show that these five divalent cations are usually competitors of ZIP14- and/or ZIP8-mediated Zn uptake; our data thus support the possible involvement of intestinal ZIP14 for uptake of these five metals into the body and ZIP8 for efficient uptake into the kidney.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.