ArticleCell research2013
Cytokinin signaling regulates pavement cell morphogenesis in Arabidopsis.
Article in Cell research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 49 citations in OpenAlex.
- Phytohormonal regulation of root exudation: mechanisms and rhizosphere function.Plant signaling & behavior · 2025Review
- Hierarchical global and local auxin signals coordinate cellular interdigitation inbioRxiv : the preprint server for biology · 2024Article
- Mechano-chemical regulation of complex cell shape formation: Epidermal pavement cells-A case study.Quantitative plant biology · 2023Review
- Cell biology of the leaf epidermis: Fate specification, morphogenesis, and coordination.The Plant cell · 2022Review
- Cytokinin-microbiome interactions regulate developmental functions.Environmental microbiome · 2022Article
- Combined Metabolome and Transcriptome Analyses of Young, Mature, and Old Rhizome Tissues ofFrontiers in genetics · 2021Article
- Cell polarity: Regulators and mechanisms in plants.Journal of integrative plant biology · 2020Review
- Actin Reorganization Triggers Rapid Cell Elongation in Roots.Plant physiology · 2018Article
- PaCeQuant: A Tool for High-Throughput Quantification of Pavement Cell Shape Characteristics.Plant physiology · 2017Article
- Pavement cells: a model system for non-transcriptional auxin signalling and crosstalks.Journal of experimental botany · 2015Review
- TYPE-ONE PROTEIN PHOSPHATASE4 regulates pavement cell interdigitation by modulating PIN-FORMED1 polarity and trafficking in Arabidopsis.Plant physiology · 2015Article
- Patatin-related phospholipase pPLAIIIδ influences auxin-responsive cell morphology and organ size in Arabidopsis and Brassica napus.BMC plant biology · 2014Article
- Cytokinins.The arabidopsis book · 2014Article
- Plant cell shape: modulators and measurements.Frontiers in plant science · 2013Review
- A robust and sensitive synthetic sensor to monitor the transcriptional output of the cytokinin signaling network in planta.Plant physiology · 2013Article
Corrections and comments
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Authors and funding
14 authors at 8 institutions in 5 countries.
Funding
Abstract
The puzzle piece-shaped Arabidopsis leaf pavement cells (PCs) with interdigitated lobes and indents is a good model system to investigate the mechanisms that coordinate cell polarity and shape formation within a tissue. Auxin has been shown to coordinate the interdigitation by activating ROP GTPase-dependent signaling pathways. To identify additional components or mechanisms, we screened for mutants with abnormal PC morphogenesis and found that cytokinin signaling regulates the PC interdigitation pattern. Reduction in cytokinin accumulation and defects in cytokinin signaling (such as in ARR7-over-expressing lines, the ahk3cre1 cytokinin receptor mutant, and the ahp12345 cytokinin signaling mutant) enhanced PC interdigitation, whereas over-production of cytokinin and over-activation of cytokinin signaling in an ARR20 over-expression line delayed or abolished PC interdigitation throughout the cotyledon. Genetic and biochemical analyses suggest that cytokinin signaling acts upstream of ROPs to suppress the formation of interdigitated pattern. Our results provide novel mechanistic understanding of the pathways controlling PC shape and uncover a new role for cytokinin signaling in cell morphogenesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.